DrugMapper


Display Options: Drug type Therapeutic Area Route of administration Mechanism of Action Indication Status		Total: 139


Small molecule Approved OTHER ORAL Bacterial Infections Penicillin-binding protein inhibitor


Small molecule Approved OTHER INJECTION HIV Wasting Syndrome; Hip Fractures; Malnutrition; Eye Diseases Androgen Receptor agonist


Small molecule Approved OTHER INHALATION Unknown Beta-2 adrenergic receptor agonist


Small molecule Approved OTHER ORAL Arthritis, Rheumatoid; Cerebral Hemorrhage; Pre-Eclampsia; Proteinuria; Heart Failure; Hypertension; Ventricular Dysfunction, Left Angiotensin-converting enzyme inhibitor


Small molecule Approved Unknown Unknown Barrett Esophagus; Erectile Dysfunction; Ischemia; Renal Insufficiency, Chronic; Cerebral Hemorrhage; Diabetes Mellitus, Type 1; Essential Hypertension; Glomerulonephritis, IGA; Heart Diseases; Melanoma; Pseudohypoaldosteronism; Stroke; Cardiomyopathies; Cardiotoxicity; Chagas Cardiomyopathy; Heart Failure; Hypertension; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Multiple Myeloma; Myocardial Ischemia; Neoplasms; Severe Acute Respiratory Syndrome; ST Elevation Myocardial Infarction; Cardiovascular Diseases Unknown

Small molecule

Approved

Unknown

Barrett Esophagus; Erectile Dysfunction; Ischemia; Renal Insufficiency, Chronic; Cerebral Hemorrhage; Diabetes Mellitus, Type 1; Essential Hypertension; Glomerulonephritis, IGA; Heart Diseases; Melanoma; Pseudohypoaldosteronism; Stroke; Cardiomyopathies; Cardiotoxicity; Chagas Cardiomyopathy; Heart Failure; Hypertension; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Multiple Myeloma; Myocardial Ischemia; Neoplasms; Severe Acute Respiratory Syndrome; ST Elevation Myocardial Infarction; Cardiovascular Diseases

Unknown


Small molecule Approved OTHER INJECTION Delirium; Conduct Disorder; Psychotic Disorders; Schizophrenia; Tourette Syndrome D2-like dopamine receptor inverse agonist


Small molecule Approved CARDIOVASCULAR; OTHER ORAL Inflammation; Asthma; Leukemia, Myeloid, Acute; Metabolic Diseases; Porokeratosis; Stroke; Arthritis, Rheumatoid; Breast Neoplasms; Carotid Stenosis; Cognitive Dysfunction; Fragile X Syndrome; Heart Diseases; HIV Infections; Intracranial Arteriosclerosis; Intracranial Arteriovenous Malformations; Learning Disabilities; Melanoma; Neurofibromatosis 1; Ovarian Neoplasms; Parkinson Disease; Prostatic Neoplasms, Castration-Resistant; Pulmonary Disease, Chronic Obstructive; Rett Syndrome; Xanthomatosis, Cerebrotendinous; Intermittent Claudication; Lipid Metabolism Disorders; Myocardial Ischemia; Atherosclerosis; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Hypercholesterolemia; Hypothyroidism HMG-CoA reductase inhibitor

Small molecule

Approved

CARDIOVASCULAR; OTHER

ORAL

Inflammation; Asthma; Leukemia, Myeloid, Acute; Metabolic Diseases; Porokeratosis; Stroke; Arthritis, Rheumatoid; Breast Neoplasms; Carotid Stenosis; Cognitive Dysfunction; Fragile X Syndrome; Heart Diseases; HIV Infections; Intracranial Arteriosclerosis; Intracranial Arteriovenous Malformations; Learning Disabilities; Melanoma; Neurofibromatosis 1; Ovarian Neoplasms; Parkinson Disease; Prostatic Neoplasms, Castration-Resistant; Pulmonary Disease, Chronic Obstructive; Rett Syndrome; Xanthomatosis, Cerebrotendinous; Intermittent Claudication; Lipid Metabolism Disorders; Myocardial Ischemia; Atherosclerosis; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Hypercholesterolemia; Hypothyroidism

HMG-CoA reductase inhibitor


Small molecule Approved OTHER IMPLANTATION; INHALATION; NASAL; TOPICAL Hypersensitivity; Spinal Cord Injuries; Anemia, Sickle Cell; Dermatitis, Atopic; Eosinophilic Esophagitis; Pemphigoid, Bullous; Psoriasis; Breast Neoplasms; Hypertrophy; Otitis Media with Effusion; Pulmonary Disease, Chronic Obstructive; Rhinitis, Allergic, Perennial; Severe Acute Respiratory Syndrome; Sinusitis; Sleep Apnea, Obstructive; Asthma; Lung Diseases, Obstructive; Nasal Obstruction; Nasal Polyps; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal; Skin Diseases Glucocorticoid receptor agonist

Small molecule

Approved

OTHER

IMPLANTATION; INHALATION; NASAL; TOPICAL

Hypersensitivity; Spinal Cord Injuries; Anemia, Sickle Cell; Dermatitis, Atopic; Eosinophilic Esophagitis; Pemphigoid, Bullous; Psoriasis; Breast Neoplasms; Hypertrophy; Otitis Media with Effusion; Pulmonary Disease, Chronic Obstructive; Rhinitis, Allergic, Perennial; Severe Acute Respiratory Syndrome; Sinusitis; Sleep Apnea, Obstructive; Asthma; Lung Diseases, Obstructive; Nasal Obstruction; Nasal Polyps; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal; Skin Diseases

Glucocorticoid receptor agonist


Small molecule Approved OTHER INJECTION; ORAL Severe Combined Immunodeficiency; Castleman Disease; Infections; Leukemia-Lymphoma, Adult T-Cell; Liver Cirrhosis, Biliary; Lymphoma; Lymphoma, AIDS-Related; Paraparesis, Tropical Spastic; Sarcoma, Kaposi; Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; AIDS-Related Complex; Diarrhea; Pneumonia, Pneumocystis; Pregnancy; Severe Acute Respiratory Syndrome; Tuberculosis; Autoimmune Diseases; HIV Infections; Virus Diseases Human immunodeficiency virus type 1 reverse transcriptase inhibitor

Small molecule

Approved

OTHER

INJECTION; ORAL

Severe Combined Immunodeficiency; Castleman Disease; Infections; Leukemia-Lymphoma, Adult T-Cell; Liver Cirrhosis, Biliary; Lymphoma; Lymphoma, AIDS-Related; Paraparesis, Tropical Spastic; Sarcoma, Kaposi; Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; AIDS-Related Complex; Diarrhea; Pneumonia, Pneumocystis; Pregnancy; Severe Acute Respiratory Syndrome; Tuberculosis; Autoimmune Diseases; HIV Infections; Virus Diseases

Human immunodeficiency virus type 1 reverse transcriptase inhibitor


Small molecule Approved OTHER; RESPIRATORY ORAL Osteomyelitis; Bronchitis, Chronic; Infections; Maxillary Sinusitis; Otitis Media; Pharyngitis; Pneumonia; Sinusitis; Tonsillitis; Urinary Tract Infections Bacterial penicillin-binding protein inhibitor


Small molecule Approved OTHER INJECTION Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neoplasm Metastasis; Breast Neoplasms; Burkitt Lymphoma; Leukemia, Myeloid, Acute; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Nasopharyngeal Neoplasms; Pancreatic Neoplasms; Penile Neoplasms; Peritoneal Neoplasms; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Urethral Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms; Wilms Tumor; Carcinoma; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Dermatofibrosarcoma; Endometrial Neoplasms; Fallopian Tube Neoplasms; Fibrosarcoma; Hemangiopericytoma; Hemangiosarcoma; Histiocytoma; Hodgkin Disease; Kidney Neoplasms; Leiomyosarcoma; Leukemia; Leukemia, Biphenotypic, Acute; Liposarcoma; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Mediastinal Neoplasms; Mesenchymoma; Neoplasms, Germ Cell and Embryonal; Neurilemmoma; Neuroblastoma; Osteosarcoma; Ovarian Neoplasms; Pheochromocytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retroviridae Infections; Rhabdomyosarcoma; Sarcoma; Sarcoma, Alveolar Soft Part; Sarcoma, Ewing; Sarcoma, Synovial; Small Cell Lung Carcinoma; Teratoma; Uterine Cervical Neoplasms; Neoplasms; Testicular Neoplasms DNA inhibitor

Small molecule

Approved

OTHER

INJECTION

Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neoplasm Metastasis; Breast Neoplasms; Burkitt Lymphoma; Leukemia, Myeloid, Acute; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Nasopharyngeal Neoplasms; Pancreatic Neoplasms; Penile Neoplasms; Peritoneal Neoplasms; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Urethral Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms; Wilms Tumor; Carcinoma; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Dermatofibrosarcoma; Endometrial Neoplasms; Fallopian Tube Neoplasms; Fibrosarcoma; Hemangiopericytoma; Hemangiosarcoma; Histiocytoma; Hodgkin Disease; Kidney Neoplasms; Leiomyosarcoma; Leukemia; Leukemia, Biphenotypic, Acute; Liposarcoma; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Mediastinal Neoplasms; Mesenchymoma; Neoplasms, Germ Cell and Embryonal; Neurilemmoma; Neuroblastoma; Osteosarcoma; Ovarian Neoplasms; Pheochromocytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retroviridae Infections; Rhabdomyosarcoma; Sarcoma; Sarcoma, Alveolar Soft Part; Sarcoma, Ewing; Sarcoma, Synovial; Small Cell Lung Carcinoma; Teratoma; Uterine Cervical Neoplasms; Neoplasms; Testicular Neoplasms

DNA inhibitor


Small molecule Approved OTHER ORAL Infections; Abortion, Incomplete; Clostridium Infections; Muscle Cramp; Premature Birth; Abortion, Spontaneous; Leiomyoma; Menorrhagia; Obesity; Pain; Postpartum Hemorrhage; Pre-Eclampsia; Pregnancy; Spondylitis, Ankylosing; Uterine Diseases; Duodenal Ulcer; Gastroesophageal Reflux; Hemorrhage; Osteoarthritis; Peptic Ulcer; Stomach Ulcer Prostanoid EP3 receptor agonist

Small molecule

Approved

OTHER

ORAL

Infections; Abortion, Incomplete; Clostridium Infections; Muscle Cramp; Premature Birth; Abortion, Spontaneous; Leiomyoma; Menorrhagia; Obesity; Pain; Postpartum Hemorrhage; Pre-Eclampsia; Pregnancy; Spondylitis, Ankylosing; Uterine Diseases; Duodenal Ulcer; Gastroesophageal Reflux; Hemorrhage; Osteoarthritis; Peptic Ulcer; Stomach Ulcer

Prostanoid EP3 receptor agonist


Small molecule Approved GASTROINTESTINAL; OTHER ORAL Pancreatic Neoplasms; Alzheimer Disease; Anemia; Arthritis, Rheumatoid; Carcinoma, Medullary; Central Serous Chorioretinopathy; Child Development Disorders, Pervasive; Chronic Pain; Clostridium Infections; Colitis, Ulcerative; Communicable Diseases; Crohn Disease; Dermatitis, Atopic; Diabetes Mellitus; Diabetes Mellitus, Type 2; Erectile Dysfunction; Glaucoma; Hepatitis C; Hepatitis C, Chronic; HIV Infections; Laryngomalacia; Melanoma; Mitochondrial Diseases; Muscular Atrophy, Spinal; Neoplasms; Psoriasis; Pulmonary Disease, Chronic Obstructive; Breast Neoplasms; Carcinoma, Squamous Cell; Colorectal Neoplasms; Cystic Fibrosis; Gastrinoma; Granuloma; Head and Neck Neoplasms; Idiopathic Pulmonary Fibrosis; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Prostatic Neoplasms, Castration-Resistant; Squamous Cell Carcinoma of Head and Neck; Squamous Intraepithelial Lesions; Ulcer; Zollinger-Ellison Syndrome; Barrett Esophagus; Cough; Cysticercosis; Diabetes Mellitus, Type 1; Dyspepsia; Esophagitis, Peptic; Exocrine Pancreatic Insufficiency; Gastrointestinal Hemorrhage; Helicobacter Infections; Hemorrhage; Multiple Sclerosis, Relapsing-Remitting; Osteoarthritis; Pain; Spondylitis, Ankylosing; Stomach Neoplasms; Wounds and Injuries; Duodenal Ulcer; Esophagitis; Gastroesophageal Reflux; Heartburn; Infections; Peptic Ulcer; Stomach Ulcer Potassium-transporting ATPase inhibitor

Small molecule

Approved

GASTROINTESTINAL; OTHER

ORAL

Pancreatic Neoplasms; Alzheimer Disease; Anemia; Arthritis, Rheumatoid; Carcinoma, Medullary; Central Serous Chorioretinopathy; Child Development Disorders, Pervasive; Chronic Pain; Clostridium Infections; Colitis, Ulcerative; Communicable Diseases; Crohn Disease; Dermatitis, Atopic; Diabetes Mellitus; Diabetes Mellitus, Type 2; Erectile Dysfunction; Glaucoma; Hepatitis C; Hepatitis C, Chronic; HIV Infections; Laryngomalacia; Melanoma; Mitochondrial Diseases; Muscular Atrophy, Spinal; Neoplasms; Psoriasis; Pulmonary Disease, Chronic Obstructive; Breast Neoplasms; Carcinoma, Squamous Cell; Colorectal Neoplasms; Cystic Fibrosis; Gastrinoma; Granuloma; Head and Neck Neoplasms; Idiopathic Pulmonary Fibrosis; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Prostatic Neoplasms, Castration-Resistant; Squamous Cell Carcinoma of Head and Neck; Squamous Intraepithelial Lesions; Ulcer; Zollinger-Ellison Syndrome; Barrett Esophagus; Cough; Cysticercosis; Diabetes Mellitus, Type 1; Dyspepsia; Esophagitis, Peptic; Exocrine Pancreatic Insufficiency; Gastrointestinal Hemorrhage; Helicobacter Infections; Hemorrhage; Multiple Sclerosis, Relapsing-Remitting; Osteoarthritis; Pain; Spondylitis, Ankylosing; Stomach Neoplasms; Wounds and Injuries; Duodenal Ulcer; Esophagitis; Gastroesophageal Reflux; Heartburn; Infections; Peptic Ulcer; Stomach Ulcer

Potassium-transporting ATPase inhibitor


Small molecule Approved OTHER; UROLOGY AND KIDNEY ORAL Adrenal Hyperplasia, Congenital; Ovarian Neoplasms; Polycystic Ovary Syndrome; Prostatic Neoplasms, Castration-Resistant; Carcinoma; Neoplasms; Prostatic Neoplasms Androgen Receptor antagonist


Small molecule Approved Unknown Unknown Cystic Fibrosis; Hepatitis C; HIV Infections; Migraine Disorders; Metrorrhagia; Osteoporosis; Neural Tube Defects; Acne Vulgaris Progesterone receptor agonist


Small molecule Approved EYE; OTHER IMPLANTATION; OPHTHALMIC; ORAL Central Nervous System Neoplasms; Kidney Diseases; Melanoma; Mesothelioma; Neuroblastoma; Carcinoma, Hepatocellular; Diabetes Mellitus, Type 1; Fallopian Tube Neoplasms; Glioblastoma; Graft vs Host Disease; Lymphoma; Ovarian Neoplasms; Peritoneal Neoplasms; Conjunctivitis; Cytomegalovirus Infections; Infections; Acquired Immunodeficiency Syndrome; Cytomegalovirus Retinitis; Eye Infections; HIV Infections; Primary Immunodeficiency Diseases; Retinitis; Virus Diseases Human herpesvirus 1 DNA polymerase inhibitor

Small molecule

Approved

EYE; OTHER

IMPLANTATION; OPHTHALMIC; ORAL

Central Nervous System Neoplasms; Kidney Diseases; Melanoma; Mesothelioma; Neuroblastoma; Carcinoma, Hepatocellular; Diabetes Mellitus, Type 1; Fallopian Tube Neoplasms; Glioblastoma; Graft vs Host Disease; Lymphoma; Ovarian Neoplasms; Peritoneal Neoplasms; Conjunctivitis; Cytomegalovirus Infections; Infections; Acquired Immunodeficiency Syndrome; Cytomegalovirus Retinitis; Eye Infections; HIV Infections; Primary Immunodeficiency Diseases; Retinitis; Virus Diseases

Human herpesvirus 1 DNA polymerase inhibitor


Small molecule Approved Unknown Unknown Spondylitis, Ankylosing Unknown


Small molecule Approved CARDIOVASCULAR; OTHER ORAL Heart Failure; Hemangioma, Cavernous, Central Nervous System; Lymphoma; Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Alopecia Areata; Anemia, Sickle Cell; Arthritis, Rheumatoid; Choroideremia; Chronic Pain; Cystic Fibrosis; Epilepsy; Hepatitis B, Chronic; HIV Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Lupus Erythematosus, Systemic; Sleep Initiation and Maintenance Disorders; Sleep Wake Disorders; Vascular Diseases; Atrial Fibrillation; Bipolar Disorder; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cardiomyopathy, Dilated; Carotid Artery Diseases; Cerebral Hemorrhage; Diabetes Mellitus, Type 1; Hypertension, Pulmonary; Intermittent Claudication; Leiomyoma; Lung Neoplasms; Migraine Disorders; Mucositis; Multiple Myeloma; Pancreatic Neoplasms; Pancreatitis; Parkinson Disease; Periodontitis; Peripheral Arterial Disease; Prediabetic State; Prostatic Neoplasms; Rectal Neoplasms; Sepsis; Shock, Septic; Sinusitis; Small Cell Lung Carcinoma; Smith-Lemli-Opitz Syndrome; Smoking Cessation; Urinary Bladder Neoplasms; Uveitis; Vitiligo; Waldenstrom Macroglobulinemia; Acute Coronary Syndrome; Alzheimer Disease; Aortic Valve Stenosis; Asthma; Atherosclerosis; Cholangitis, Sclerosing; Colorectal Neoplasms; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Retinopathy; Essential Hypertension; Graves Ophthalmopathy; Hyperlipidemia, Familial Combined; Hypertension; Hypertension, Portal; Hypertriglyceridemia; Inflammation; Intestinal Neoplasms; Ischemic Stroke; Lipid Metabolism Disorders; Liver Cirrhosis; Metabolic Syndrome; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Myocardial Ischemia; Noonan Syndrome; Optic Neuritis; Pneumonia; Polycystic Ovary Syndrome; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Severe Acute Respiratory Syndrome; Stomach Neoplasms; Subarachnoid Hemorrhage; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Diabetes Mellitus, Type 2; Dyslipidemias; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II; Myocardial Infarction; Stroke HMG-CoA reductase inhibitor

Small molecule

Approved

CARDIOVASCULAR; OTHER

ORAL

Heart Failure; Hemangioma, Cavernous, Central Nervous System; Lymphoma; Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Alopecia Areata; Anemia, Sickle Cell; Arthritis, Rheumatoid; Choroideremia; Chronic Pain; Cystic Fibrosis; Epilepsy; Hepatitis B, Chronic; HIV Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Lupus Erythematosus, Systemic; Sleep Initiation and Maintenance Disorders; Sleep Wake Disorders; Vascular Diseases; Atrial Fibrillation; Bipolar Disorder; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cardiomyopathy, Dilated; Carotid Artery Diseases; Cerebral Hemorrhage; Diabetes Mellitus, Type 1; Hypertension, Pulmonary; Intermittent Claudication; Leiomyoma; Lung Neoplasms; Migraine Disorders; Mucositis; Multiple Myeloma; Pancreatic Neoplasms; Pancreatitis; Parkinson Disease; Periodontitis; Peripheral Arterial Disease; Prediabetic State; Prostatic Neoplasms; Rectal Neoplasms; Sepsis; Shock, Septic; Sinusitis; Small Cell Lung Carcinoma; Smith-Lemli-Opitz Syndrome; Smoking Cessation; Urinary Bladder Neoplasms; Uveitis; Vitiligo; Waldenstrom Macroglobulinemia; Acute Coronary Syndrome; Alzheimer Disease; Aortic Valve Stenosis; Asthma; Atherosclerosis; Cholangitis, Sclerosing; Colorectal Neoplasms; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Retinopathy; Essential Hypertension; Graves Ophthalmopathy; Hyperlipidemia, Familial Combined; Hypertension; Hypertension, Portal; Hypertriglyceridemia; Inflammation; Intestinal Neoplasms; Ischemic Stroke; Lipid Metabolism Disorders; Liver Cirrhosis; Metabolic Syndrome; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Myocardial Ischemia; Noonan Syndrome; Optic Neuritis; Pneumonia; Polycystic Ovary Syndrome; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Severe Acute Respiratory Syndrome; Stomach Neoplasms; Subarachnoid Hemorrhage; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Diabetes Mellitus, Type 2; Dyslipidemias; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II; Myocardial Infarction; Stroke

HMG-CoA reductase inhibitor


Small molecule Approved Unknown Unknown Cardiovascular Diseases Unknown


Small molecule Approved Unknown Unknown Carotid Stenosis; Peripheral Arterial Disease; Thrombosis Unknown


Small molecule Approved OTHER ORAL Arthritis, Rheumatoid; Osteoarthritis; Rheumatic Diseases Cyclooxygenase-2 inhibitor


Small molecule Approved Unknown Unknown Lupus Erythematosus, Systemic; Nephritis, Hereditary; Atherosclerosis; Coronary Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypercholesterolemia; Hypertension; Cardiovascular Diseases Unknown


Small molecule Approved Unknown Unknown Diabetic Nephropathies; Heart Diseases; Hypertension; Cardiovascular Diseases Unknown


Small molecule Approved OTHER TOPICAL Psoriasis; Candidiasis; Eczema; Tinea Pedis; Adrenal Hyperplasia, Congenital; Anemia; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Brain Neoplasms; Bursitis; Conjunctivitis, Allergic; Dermatitis, Atopic; Endocrine System Diseases; Inflammation; Multiple Sclerosis; Neoplasms; Osteoarthritis; Peptic Ulcer; Rhinitis, Allergic; Skin Diseases; Spondylitis; Tenosynovitis; Uveitis, Posterior Glucocorticoid receptor agonist

Small molecule

Approved

OTHER

TOPICAL

Psoriasis; Candidiasis; Eczema; Tinea Pedis; Adrenal Hyperplasia, Congenital; Anemia; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Brain Neoplasms; Bursitis; Conjunctivitis, Allergic; Dermatitis, Atopic; Endocrine System Diseases; Inflammation; Multiple Sclerosis; Neoplasms; Osteoarthritis; Peptic Ulcer; Rhinitis, Allergic; Skin Diseases; Spondylitis; Tenosynovitis; Uveitis, Posterior

Glucocorticoid receptor agonist


Small molecule Approved OTHER ORAL Osteomyelitis; Otitis Media Bacterial penicillin-binding protein inhibitor

Small molecule

Approved

CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER

ORAL

Cholangitis, Sclerosing; Alcoholism; Burns; Diabetic Nephropathies; HIV Infections; Huntington Disease; Metabolic Syndrome; Multiple Myeloma; Non-alcoholic Fatty Liver Disease; Obesity; Atherosclerosis; Coronary Disease; Diabetic Retinopathy; Hyperlipidemia, Familial Combined; Hyperlipidemias; Hyperlipoproteinemias; Hyperlipoproteinemia Type III; Hypertension; Hypertriglyceridemia; Lipid Metabolism Disorders; Lipodystrophy; Liver Cirrhosis, Biliary; Metabolic Diseases; Cardiovascular Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dyslipidemias; Hypercholesterolemia; Hypothyroidism

Peroxisome proliferator-activated receptor alpha agonist


Small molecule Approved Unknown Unknown Amphetamine-Related Disorders; Stress Disorders, Post-Traumatic; Substance-Related Disorders; Alzheimer Disease; Aortic Aneurysm, Abdominal; Breast Neoplasms; Neoplasms; Cardiomyopathy, Dilated; Diabetes Mellitus, Type 2; Hypertension; Marfan Syndrome; Cardiovascular Diseases Unknown


Small molecule Approved IMMUNE SYSTEM; OTHER ORAL Herpes Simplex; Meniere Disease; Autoimmune Diseases; Eye Infections; Herpes Genitalis; Herpes Labialis; Herpes Zoster; Virus Diseases Human herpesvirus 1 DNA polymerase inhibitor


Small molecule Approved Unknown Unknown Liver Cirrhosis, Biliary; Cardiovascular Diseases Unknown

Small molecule

Approved

CARDIOVASCULAR; IMMUNE SYSTEM; OTHER

ORAL

Neoplasms, Neuroepithelial; Arthritis, Rheumatoid; beta-Thalassemia; Carcinoma, Renal Cell; DiGeorge Syndrome; Gliosarcoma; Hypertension; Lecithin Cholesterol Acyltransferase Deficiency; Lymphoma, T-Cell; Pancreatic Neoplasms; Scleroderma, Diffuse; Amyotrophic Lateral Sclerosis; Anemia, Aplastic; Anemia, Sickle Cell; Autoimmune Diseases; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Crohn Disease; Epidermolysis Bullosa; Fanconi Anemia; Gout; Granuloma, Lethal Midline; Hematologic Diseases; Hematologic Neoplasms; Hemoglobinuria, Paroxysmal; Hepatitis, Alcoholic; Histiocytosis, Langerhans-Cell; HIV Infections; Hyperlipoproteinemia Type I; Immunoblastic Lymphadenopathy; Kidney Neoplasms; Leukemia, Hairy Cell; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Mast-Cell; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; Leukemia, Prolymphocytic, B-Cell; Leukemia, Prolymphocytic, T-Cell; Liver Diseases; Lymphoma; Lymphoma, Follicular; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Peripheral; Macular Degeneration; Melanoma; Multiple Sclerosis; Mycosis Fungoides; Myeloproliferative Disorders; Neuroblastoma; Neuronal Ceroid-Lipofuscinoses; Pemphigoid, Benign Mucous Membrane; Pemphigoid, Bullous; Polycythemia Vera; Primary Myelofibrosis; Psoriasis; Purpura, Schoenlein-Henoch; Scleroderma, Limited; Scleroderma, Systemic; Severe Combined Immunodeficiency; Sezary Syndrome; Shwachman-Diamond Syndrome; Sjogren's Syndrome; Vasculitis; Wiskott-Aldrich Syndrome; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Carcinoma, Hepatocellular; Cardiovascular Diseases; Cystitis, Interstitial; Cytomegalovirus Infections; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Glomerulonephritis, IGA; Glomerulonephritis, Membranous; Glomerulosclerosis, Focal Segmental; Graft vs Host Disease; Granulomatosis with Polyangiitis; Heart Diseases; Hepatitis C; Hodgkin Disease; Kidney Diseases; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Lung Diseases, Interstitial; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microscopic Polyangiitis; Multiple Myeloma; Myasthenia Gravis; Myelodysplastic Syndromes; Neoplasms; Nephrotic Syndrome; Neuromyelitis Optica; Pemphigus; Polyradiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Red-Cell Aplasia, Pure; Renal Insufficiency; Renal Insufficiency, Chronic; Sarcoidosis, Pulmonary; Takayasu Arteritis; Uveitis; Waldenstrom Macroglobulinemia

Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor

Small molecule

Approved

DIABETES DRUGS & ENDOCRINOLOGY; OTHER

INJECTION

Chordoma; Fanconi Anemia; Kidney Neoplasms; Leukemia, Myeloid, Acute; Liver Neoplasms; Mesothelioma; Myeloproliferative Disorders; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Retinoblastoma; Breast Neoplasms; Central Nervous System Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Hodgkin Disease; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Myelodysplastic Syndromes; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Squamous Cell; Hepatoblastoma; Lung Neoplasms; Multiple Myeloma; Nasopharyngeal Neoplasms; Peripheral Nervous System Diseases; Trigeminal Neuralgia; Head and Neck Neoplasms; Ovarian Neoplasms; Xerostomia

Reactive metabolite scavenging agent

Small molecule

Approved

Unknown

Ependymoma; Glioma; Infectious Mononucleosis; Lung Neoplasms; Prostatic Neoplasms; Astrocytoma; Bipolar Disorder; Cytomegalovirus Infections; Glioblastoma; Hepatitis C, Chronic; Leukemia, Lymphocytic, Chronic, B-Cell; Neuralgia, Postherpetic; Psychotic Disorders; Pulmonary Disease, Chronic Obstructive; Schizophrenia; Stomatitis, Herpetic; Waldenstrom Macroglobulinemia; Encephalitis; Herpes Simplex; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Herpes Genitalis; Herpes Labialis; Herpes Zoster; Virus Diseases

Unknown


Small molecule Approved DERMATOLOGY ORAL Osteomyelitis; Bacterial Infections Bacterial 70S ribosome inhibitor


Small molecule Approved DIABETES DRUGS & ENDOCRINOLOGY; OTHER ORAL Cardiovascular Diseases; Heart Failure; Hypertension; Myocardial Infarction; Ventricular Dysfunction, Left Angiotensin-converting enzyme inhibitor

Small molecule

Approved

Unknown

Desmoplastic Small Round Cell Tumor; Astrocytoma; Bone Neoplasms; Carcinoid Tumor; Diffuse Intrinsic Pontine Glioma; Digestive System Neoplasms; Endometrial Neoplasms; Kidney Neoplasms; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Mesothelioma; Oligodendroglioma; Biliary Tract Neoplasms; Carcinoma; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Fallopian Tube Neoplasms; Ganglioneuroblastoma; Glioblastoma; Glioma; Gliosarcoma; Head and Neck Neoplasms; Hemangiosarcoma; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Medulloblastoma; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Pinealoma; Pulmonary Disease, Chronic Obstructive; Rhabdomyosarcoma; Sarcoma; Wilms Tumor; Adenocarcinoma, Mucinous; Brain Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Cholangiocarcinoma; Choroid Plexus Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Hepatoblastoma; Lung Neoplasms; Neoplasm Metastasis; Pancreatic Neoplasms; Rectal Neoplasms; Sarcoma, Ewing; Small Cell Lung Carcinoma; Stomach Neoplasms; Uterine Cervical Neoplasms; Neoplasms

Unknown