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Total: 6532
Small molecule
Approved
OTHER
ORAL
Diabetes Mellitus; Diabetes Mellitus, Type 2
Sulfonylurea receptor 1, Kir6.2 blocker
Small molecule
Approved
OTHER
INJECTION; ORAL
Premature Birth; Diabetes Mellitus; Dyspnea; Edema; Leukemia; Leukemia, Myeloid, Acute; Schizophrenia; Acute Kidney Injury; Acute Lung Injury; Bronchopulmonary Dysplasia; Hypertension, Pregnancy-Induced; Keratosis, Actinic; Nasal Polyps; Neoplasms; Renal Insufficiency, Chronic; Atherosclerosis; Bronchiolitis; Coronary Disease; Diabetes Mellitus, Type 2; Essential Hypertension; Hypercholesterolemia; Kidney Diseases; Lung Diseases; Myocardial Infarction; Pre-Eclampsia; Pulmonary Embolism; Renal Insufficiency; Tachypnea; Warts; Cardiovascular Diseases; Fibrosis; Heart Failure; Hypertension; Liver Cirrhosis; Nephrotic Syndrome; Pulmonary Edema; Syndrome
Sodium-(potassium)-chloride cotransporter 2 inhibitor
Small molecule
Approved
OTHER
ORAL
Psychotic Disorders; Schizophrenia
Dopamine D2 receptor antagonist
Small molecule
Unknown
Unknown
Unknown
Unknown
Unknown
Small molecule
Approved
DENTISTRY; OTHER
INJECTION; ORAL; PERIODONTAL
Pelvic Inflammatory Disease; Tennis Elbow; Macular Degeneration; Mucositis; Sexually Transmitted Diseases, Bacterial; Telangiectasia, Hereditary Hemorrhagic; Chlamydia Infections; Periodontitis; Rosacea; Acne Vulgaris
Bacterial 70S ribosome inhibitor
Small molecule
Approved
OTHER
ORAL
Glaucoma; Urinary Bladder Neoplasms; Cardiovascular Diseases; Fibrosis; Heart Failure; Kidney Diseases; Nephrotic Syndrome; Pulmonary Edema
Sodium-(potassium)-chloride cotransporter 2 inhibitor
Small molecule
Approved
OTHER
INJECTION; ORAL
Anxiety; Dementia; Depressive Disorder; Schizophrenia; Psychotic Disorders
Dopamine D2 receptor antagonist
Small molecule
Approved
OTHER
ORAL
Lymphoma, T-Cell, Cutaneous; Osteomyelitis; Melanoma; Adenomatous Polyposis Coli; Amyloidosis; Amyloidosis, Familial; Aneurysm; Aortic Aneurysm, Abdominal; Blepharitis; Carcinoma, Non-Small-Cell Lung; Colitis, Ulcerative; Colorectal Neoplasms; Crohn Disease; Cystic Fibrosis; Dermatitis, Atopic; Diabetic Foot; Diabetic Retinopathy; Dry Eye Syndromes; Eczema; Eye Burns; Graves Ophthalmopathy; Lichen Planus, Oral; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Mansonelliasis; Marfan Syndrome; Mycosis Fungoides; Myocardial Infarction; Neoplasms; Pain; Pancreatic Neoplasms; Pelvic Inflammatory Disease; Plague; Reperfusion Injury; Seizures; Sezary Syndrome; Squamous Cell Carcinoma of Head and Neck; Tuberculosis; Alzheimer Disease; Arthritis, Reactive; Chlamydia Infections; Elephantiasis, Filarial; Hemorrhage; Idiopathic Pulmonary Fibrosis; Lyme Disease; Lymphoma; Osteoarthritis; Persian Gulf Syndrome; Pleural Effusion; Pulmonary Disease, Chronic Obstructive; Scrub Typhus; Severe Acute Respiratory Syndrome; Syphilis; Urethritis; Acne Vulgaris; Anthrax; Bacterial Infections; Brucellosis; Cholera; Gonorrhea; Infections; Malaria; Periodontitis; Pneumonia; Psittacosis; Rocky Mountain Spotted Fever; Rosacea; Spotted Fever Group Rickettsiosis; Tularemia; Typhus, Epidemic Louse-Borne
Bacterial 70S ribosome inhibitor
Small molecule
Approved
HEMATOLOGY; OTHER
ORAL
Hypertension, Pulmonary; Lung Neoplasms; beta-Thalassemia; Central Nervous System Neoplasms; Esophageal Neoplasms; Fibromatosis, Aggressive; Gliosarcoma; Head and Neck Neoplasms; Hemoglobin SC Disease; Leukemia, Myeloid, Acute; Lymphoma; Meningioma; Multiple Sclerosis; Muscular Atrophy, Spinal; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomach Neoplasms; Carcinoma; Glioblastoma; Hematologic Diseases; Hemochromatosis; HIV Infections; Laryngeal Neoplasms; Leukemia; Leukemia, Promyelocytic, Acute; Mouth Neoplasms; Myelodysplastic Syndromes; Myeloproliferative Disorders; Paranasal Sinus Neoplasms; Pharyngeal Neoplasms; Polycythemia Vera; Primary Myelofibrosis; Stroke; Thrombocythemia, Essential; Anemia, Sickle Cell; Carcinoma, Squamous Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Melanoma; Neoplasms
Ribonucleoside-diphosphate reductase RR1 inhibitor
Small molecule
Approved
OTHER
ORAL
Myocardial Infarction; Myocardial Ischemia; Cardiovascular Diseases
Peroxisome proliferator-activated receptor alpha agonist
Small molecule
Approved
OTHER
ORAL
Osteomyelitis; Infections; Urinary Tract Infections
DNA inhibitor
Small molecule
Approved
Unknown
Unknown
Depressive Disorder
Unknown
Small molecule
Approved
Unknown
Unknown
Child Development Disorders, Pervasive; Hypoglycemia; Osteoporosis; Depressive Disorder, Major; Fibromyalgia; Hemangioma, Cavernous, Central Nervous System; Kidney Diseases; Memory Disorders; Orthostatic Intolerance; Pulmonary Disease, Chronic Obstructive; Alcohol Drinking; Anemia, Sickle Cell; Asthma; Brain Injuries; Breast Neoplasms; Burns; Carcinoma, Hepatocellular; Carcinoma, Renal Cell; Cocaine-Related Disorders; Diabetes Mellitus, Type 1; Dystocia; Hemangiosarcoma; Hypertension; Hypotension; Hypotension, Orthostatic; Low Back Pain; Lymphedema; Marfan Syndrome; Melanoma; Migraine with Aura; Migraine without Aura; Multiple Myeloma; Pain; Pancreatic Neoplasms; Panic Disorder; Papilloma; Retinopathy of Prematurity; Shoulder Pain; Sleep Apnea, Obstructive; Stomach Neoplasms; Stress Disorders, Post-Traumatic; Stroke; Substance-Related Disorders; Syncope; Wounds and Injuries; Anxiety; Ascites; Colorectal Neoplasms; Death, Sudden, Cardiac; Esophageal and Gastric Varices; Headache; Hemangioma; Hypertension, Portal; Liver Cirrhosis; Migraine Disorders; Myocardial Infarction; Myocardial Ischemia; Smoking Cessation; Tachycardia, Supraventricular; Telangiectasia, Hereditary Hemorrhagic; Ventricular Fibrillation; Cardiovascular Diseases
Unknown
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown
Small molecule
Approved
OTHER
ORAL
Helminthiasis
Tubulin inhibitor
Small molecule
Approved
Unknown
Unknown
Osteomyelitis; Dysuria; Bacterial Infections
Unknown
Small molecule
Unknown
Unknown
Unknown
Down Syndrome; Cardiovascular Diseases
Thyroid hormone receptor agonist
Small molecule
Approved
Unknown
Unknown
Leiomyoma; Acromegaly; Anovulation; Hypogonadism; Infertility, Female; Obesity; Paget Disease, Extramammary; Azoospermia; Infertility; Polycystic Ovary Syndrome
Unknown
Small molecule
Approved
Unknown
Unknown
Bipolar Disorder; Pain
Unknown
Small molecule
Approved
Unknown
Unknown
Acquired Immunodeficiency Syndrome; Mycobacterium avium-intracellulare Infection; Sarcoidosis; Mycobacterium Infections; Tuberculosis, Pulmonary; Uveitis, Anterior; Tuberculosis
Unknown
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown
Small molecule
Approved
OTHER
ORAL
Diabetes Mellitus; Pain; Hemorrhage; Dysmenorrhea; Rheumatic Diseases
Cyclooxygenase inhibitor
Small molecule
Approved
Unknown
Unknown
Carcinoma, Hepatocellular; Thalassemia; Acute Kidney Injury; Anemia, Sickle Cell; Cerebral Hemorrhage; Diabetic Foot; Ischemic Stroke; Subarachnoid Hemorrhage; beta-Thalassemia; Hemochromatosis; Severe Acute Respiratory Syndrome
Unknown
Small molecule
Approved
Unknown
Unknown
Brain Injuries; Mood Disorders; Attention Deficit Disorder with Hyperactivity; Cerebral Infarction; Cocaine-Related Disorders; Diabetes Mellitus, Type 2; Hepatitis C; Infections; Influenza, Human; Pain; Hepatitis C, Chronic; Multiple Sclerosis; Psychotic Disorders; Schizophrenia; Severe Acute Respiratory Syndrome; Parkinson Disease
Unknown
Small molecule
Approved
NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS
INTRAVENOUS; ORAL
Hepatitis B, Chronic; Cocaine-Related Disorders; Epilepsy, Reflex; HIV Infections; Nausea; Anxiety; Dementia; Depressive Disorder; Schizophrenia; Bipolar Disorder; Epilepsies, Partial; Epilepsy; Glossopharyngeal Nerve Diseases; Seizures; Trigeminal Neuralgia
Sodium channel alpha subunit blocker
Small molecule
Approved
OTHER
INJECTION; INTRAVENOUS; ORAL; RECTAL
Ankle Fractures; Brain Concussion; Delirium; Glaucoma; Tooth Diseases; Anemia, Hemolytic, Autoimmune; Arrhythmias, Cardiac; Crohn Disease; Diabetes Mellitus, Type 2; Glycogen Storage Disease Type II; Hepatitis B, Chronic; Immune System Diseases; Intervertebral Disc Degeneration; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Neoplasms; Nervous System Diseases; Obesity, Morbid; Parkinson Disease; Pruritus; Purpura, Thrombocytopenic, Idiopathic; Anxiety; Arthritis, Rheumatoid; Borderline Personality Disorder; Brain Injuries; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cleft Palate; Diabetes Mellitus, Type 1; Digestive System Diseases; Fractures, Bone; Glioma; Graft vs Host Disease; Hypertension; Hypertrophy; Immunoglobulin G4-Related Disease; Leukemia, Mast-Cell; Leukemia, T-Cell; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Mucositis; Neck Pain; Neuralgia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Pre-Eclampsia; Pulpitis; Renal Colic; Rotator Cuff Injuries; Sinusitis; Tension-Type Headache; Tonsillitis; Abdominal Pain; Chronic Pain; Diabetic Neuropathies; Ductus Arteriosus, Patent; Hemorrhage; HIV Infections; Hypospadias; Infections; Kidney Calculi; Kidney Diseases; Low Back Pain; Lupus Erythematosus, Systemic; Lupus Nephritis; Malaria; Meningitis, Bacterial; Multiple Myeloma; Multiple Sclerosis; Myopia; Nausea; Obesity; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Paget Disease, Extramammary; Pemphigus; Postoperative Nausea and Vomiting; Respiratory Tract Infections; Scoliosis; Sepsis; Severe Acute Respiratory Syndrome; Streptococcal Infections; Vomiting; Wounds and Injuries; Acute Pain; Arthritis; Back Pain; Common Cold; Dysmenorrhea; Fever; Headache; Influenza, Human; Migraine Disorders; Muscle Cramp; Pain; Pharyngitis; Toothache
Anandamide amidohydrolase inhibitor
Small molecule
Approved
OTHER
ORAL
Endometrial Neoplasms; Hemorrhage
Progesterone receptor agonist
Small molecule
Approved
Unknown
Unknown
Osteomyelitis; Bacteremia; Gram-Positive Bacterial Infections; Bacterial Infections
Unknown
Small molecule
Approved
Unknown
Unknown
Hordeolum
Cell membrane inhibitor
Small molecule
Approved
CANCER; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
BUCCAL; SUBLINGUAL; TRANSDERMAL
Opioid-Related Disorders; Respiratory Distress Syndrome; Brain Injuries; Breast Neoplasms; Bronchial Spasm; Delirium; Fractures, Bone; Hypospadias; Hypotension; Irritable Bowel Syndrome; Pulpitis; Scoliosis; Subarachnoid Hemorrhage; Abscess; Adenoma; Diabetic Neuropathies; Liver Diseases; Low Back Pain; Neoplasm Metastasis; Obesity; Obesity, Morbid; Osteoarthritis; Pancreatic Neoplasms; Renal Insufficiency, Chronic; Respiratory Insufficiency; Sleep Apnea, Obstructive; Stomach Neoplasms; Acute Pain; Cancer Pain; Chronic Pain; Migraine Disorders; Neoplasms; Pain
Mu opioid receptor agonist
Small molecule
Approved
OTHER
ORAL
Inflammatory Bowel Diseases; Mucopolysaccharidoses; Myelodysplastic Syndromes; Urticaria; Anemia, Sickle Cell; Gout; Hepatitis, Autoimmune; Idiopathic Pulmonary Fibrosis; Infertility; Leukemia, Myeloid, Acute; Lung Diseases; Lung Diseases, Interstitial; Pemphigoid, Bullous; Pemphigus; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Carcinoma, Hepatocellular; Cardiomyopathies; Churg-Strauss Syndrome; Colitis, Ulcerative; Crohn Disease; Eczema; Glomerulonephritis, IGA; Granulomatosis with Polyangiitis; Lupus Erythematosus, Systemic; Lupus Nephritis; Microscopic Polyangiitis; Myasthenia Gravis; Neuromyelitis Optica; Pulmonary Fibrosis; Renal Insufficiency, Chronic; Takayasu Arteritis; Thrombocytopenia; Vasculitis; Arthritis, Rheumatoid; Immune System Diseases
Amidophosphoribosyltransferase inhibitor
Small molecule
Approved
OTHER
ORAL
Unknown
Unknown
Small molecule
Approved
Unknown
Unknown
Glioblastoma; Central Nervous System Neoplasms; Hodgkin Disease; Lymphoma; Neoplasms
Unknown
Small molecule
Approved
OTHER
INJECTION; ORAL
Puberty, Precocious
Cytochrome P450 19A1 inhibitor
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown