DrugMapper


Display Options: Drug type Therapeutic Area Route of administration Mechanism of Action Indication Status		Total: 6532


Small molecule Approved Unknown Unknown Alcoholism; Amblyopia; Amyotrophic Lateral Sclerosis; Anemia; Arthritis, Rheumatoid; Chronic Pain; Colitis, Ulcerative; Communicable Diseases; Crohn Disease; Dermatitis, Atopic; Diabetes Mellitus, Type 2; Endotoxemia; Hepatitis C, Chronic; HIV Infections; Hypotension, Orthostatic; Melanoma; Mitochondrial Diseases; Narcolepsy; Neoplasm Metastasis; Neoplasms; Non-alcoholic Fatty Liver Disease; Prostatic Neoplasms, Castration-Resistant; Psoriasis; Severe Acute Respiratory Syndrome; Sexual Dysfunction, Physiological; Spinal Cord Injuries; Substance-Related Disorders; Voice Disorders; Breast Neoplasms; Cocaine-Related Disorders; Dyspnea; Tension-Type Headache; Alzheimer Disease; Atrial Fibrillation; Back Pain; Bronchopulmonary Dysplasia; Common Cold; Coronary Disease; Dysmenorrhea; Headache; Hypoxia; Intermittent Claudication; Low Back Pain; Migraine with Aura; Migraine without Aura; Multiple Sclerosis, Relapsing-Remitting; Neck Pain; Obesity; Parkinson Disease; Toothache; Apnea; Attention Deficit Disorder with Hyperactivity; Migraine Disorders; Pain Adenosine receptor antagonist

Small molecule

Approved

Unknown

Alcoholism; Amblyopia; Amyotrophic Lateral Sclerosis; Anemia; Arthritis, Rheumatoid; Chronic Pain; Colitis, Ulcerative; Communicable Diseases; Crohn Disease; Dermatitis, Atopic; Diabetes Mellitus, Type 2; Endotoxemia; Hepatitis C, Chronic; HIV Infections; Hypotension, Orthostatic; Melanoma; Mitochondrial Diseases; Narcolepsy; Neoplasm Metastasis; Neoplasms; Non-alcoholic Fatty Liver Disease; Prostatic Neoplasms, Castration-Resistant; Psoriasis; Severe Acute Respiratory Syndrome; Sexual Dysfunction, Physiological; Spinal Cord Injuries; Substance-Related Disorders; Voice Disorders; Breast Neoplasms; Cocaine-Related Disorders; Dyspnea; Tension-Type Headache; Alzheimer Disease; Atrial Fibrillation; Back Pain; Bronchopulmonary Dysplasia; Common Cold; Coronary Disease; Dysmenorrhea; Headache; Hypoxia; Intermittent Claudication; Low Back Pain; Migraine with Aura; Migraine without Aura; Multiple Sclerosis, Relapsing-Remitting; Neck Pain; Obesity; Parkinson Disease; Toothache; Apnea; Attention Deficit Disorder with Hyperactivity; Migraine Disorders; Pain

Adenosine receptor antagonist


Small molecule Approved Unknown Unknown Hypersensitivity; Pruritus Unknown


Small molecule Approved OTHER INJECTION Osteomyelitis; Bacterial Infections; Sepsis; Infections Unknown


Small molecule Approved OTHER ORAL Infections; Rhinitis, Allergic, Seasonal; Postoperative Nausea and Vomiting Histamine H1 receptor antagonist


Small molecule Approved Unknown Unknown Hypotension, Orthostatic; Migraine Disorders Unknown


Small molecule Approved Unknown Unknown Bacterial Infections Unknown


Small molecule Approved DENTISTRY; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER BUCCAL; ORAL; RECTAL; TOPICAL Abortion, Spontaneous; Attention Deficit Disorder with Hyperactivity; Brain Neoplasms; Carcinoma, Squamous Cell; Cicatrix; Complex Regional Pain Syndromes; Glioblastoma; Glycogen Storage Disease Type II; Hypertension, Pulmonary; Keratosis, Actinic; Lung Neoplasms; Morton Neuroma; Neoplasms, Cystic, Mucinous, and Serous; Neuroma; Parathyroid Neoplasms; Premature Birth; Radius Fractures; Skin Neoplasms; Spinal Fractures; Thromboembolism; Tinnitus; Anus Diseases; Anxiety; Cancer Pain; Carcinoma; Cocaine-Related Disorders; Cognitive Dysfunction; Cystitis, Interstitial; Diabetic Neuropathies; Dysmenorrhea; Dysphonia; Geographic Atrophy; Heart Diseases; Humeral Fractures; Infertility; Irritable Bowel Syndrome; Leiomyoma; Myofascial Pain Syndromes; Neoplasms; Renal Colic; Rib Fractures; Scleroderma, Localized; Severe Acute Respiratory Syndrome; Shoulder Impingement Syndrome; Shoulder Pain; Skin Diseases; Temporomandibular Joint Disorders; Trigeminal Neuralgia; Urinary Incontinence; Urinary Tract Infections; Analgesia; Breast Neoplasms; Carpal Tunnel Syndrome; Chronic Pain; Colorectal Neoplasms; Common Cold; Cough; Dysuria; Fibromyalgia; Fractures, Bone; Headache; Heart Arrest; Hemorrhage; Ileus; Low Back Pain; Migraine Disorders; Muscular Diseases; Nutrition Disorders; Obesity; Obesity, Morbid; Osteoarthritis, Knee; Osteoporosis, Postmenopausal; Paget Disease, Extramammary; Parathyroid Diseases; Periarthritis; Peripheral Nervous System Diseases; Pharyngitis; Pre-Eclampsia; Pregnancy; Pulpitis; Scoliosis; Shock, Septic; Sinusitis; Stomatitis; Stroke; Tennis Elbow; Urinary Bladder Neoplasms; Urinary Bladder, Overactive; Uterine Cervical Dysplasia; Wounds and Injuries; Arrhythmias, Cardiac; Arthritis; Back Pain; Burns; Bursitis; Hemorrhoids; Inflammation; Insect Bites and Stings; Muscle Cramp; Myalgia; Neuralgia; Neuralgia, Postherpetic; Osteoarthritis; Pain; Premature Ejaculation; Pruritus; Rectal Diseases; Sprains and Strains; Sunburn; Tendinopathy; Urethritis Sodium channel alpha subunit blocker

Small molecule

Approved

DENTISTRY; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

BUCCAL; ORAL; RECTAL; TOPICAL

Abortion, Spontaneous; Attention Deficit Disorder with Hyperactivity; Brain Neoplasms; Carcinoma, Squamous Cell; Cicatrix; Complex Regional Pain Syndromes; Glioblastoma; Glycogen Storage Disease Type II; Hypertension, Pulmonary; Keratosis, Actinic; Lung Neoplasms; Morton Neuroma; Neoplasms, Cystic, Mucinous, and Serous; Neuroma; Parathyroid Neoplasms; Premature Birth; Radius Fractures; Skin Neoplasms; Spinal Fractures; Thromboembolism; Tinnitus; Anus Diseases; Anxiety; Cancer Pain; Carcinoma; Cocaine-Related Disorders; Cognitive Dysfunction; Cystitis, Interstitial; Diabetic Neuropathies; Dysmenorrhea; Dysphonia; Geographic Atrophy; Heart Diseases; Humeral Fractures; Infertility; Irritable Bowel Syndrome; Leiomyoma; Myofascial Pain Syndromes; Neoplasms; Renal Colic; Rib Fractures; Scleroderma, Localized; Severe Acute Respiratory Syndrome; Shoulder Impingement Syndrome; Shoulder Pain; Skin Diseases; Temporomandibular Joint Disorders; Trigeminal Neuralgia; Urinary Incontinence; Urinary Tract Infections; Analgesia; Breast Neoplasms; Carpal Tunnel Syndrome; Chronic Pain; Colorectal Neoplasms; Common Cold; Cough; Dysuria; Fibromyalgia; Fractures, Bone; Headache; Heart Arrest; Hemorrhage; Ileus; Low Back Pain; Migraine Disorders; Muscular Diseases; Nutrition Disorders; Obesity; Obesity, Morbid; Osteoarthritis, Knee; Osteoporosis, Postmenopausal; Paget Disease, Extramammary; Parathyroid Diseases; Periarthritis; Peripheral Nervous System Diseases; Pharyngitis; Pre-Eclampsia; Pregnancy; Pulpitis; Scoliosis; Shock, Septic; Sinusitis; Stomatitis; Stroke; Tennis Elbow; Urinary Bladder Neoplasms; Urinary Bladder, Overactive; Uterine Cervical Dysplasia; Wounds and Injuries; Arrhythmias, Cardiac; Arthritis; Back Pain; Burns; Bursitis; Hemorrhoids; Inflammation; Insect Bites and Stings; Muscle Cramp; Myalgia; Neuralgia; Neuralgia, Postherpetic; Osteoarthritis; Pain; Premature Ejaculation; Pruritus; Rectal Diseases; Sprains and Strains; Sunburn; Tendinopathy; Urethritis

Sodium channel alpha subunit blocker


Small molecule Approved OTHER ORAL Unknown Histamine H1 receptor antagonist


Small molecule Approved OTHER TOPICAL Unknown Bacterial enoyl-[acyl-carrier-protein] reductase inhibitor


Small molecule Approved Unknown Unknown Hodgkin Disease; Lichen Planus; Lymphoma, T-Cell, Cutaneous; Lymphoma; Mycosis Fungoides; Neoplasms DNA inhibitor


Small molecule Approved OTHER TOPICAL Scabies Unknown


Small molecule Approved OTHER ORAL Epilepsy Voltage-gated T-type calcium channel blocker


Small molecule Approved Unknown Unknown Dystonic Disorders; Parkinson Disease Unknown


Small molecule Approved Unknown Unknown Bacterial Infections Bacterial dihydropteroate synthase inhibitor


Small molecule Approved Unknown Unknown Carcinoma, Intraductal, Noninfiltrating; Gliosarcoma; Neoplasms; Pancreatic Neoplasms; Severe Dengue; Small Cell Lung Carcinoma; Acquired Immunodeficiency Syndrome; Anemia, Sickle Cell; Brain Diseases; Breast Neoplasms; HIV Infections; Influenza, Human; Lupus Erythematosus, Systemic; Multiple Myeloma; Arthritis, Rheumatoid; Glioblastoma; Malaria, Falciparum; Malaria, Vivax; Pregnancy; Severe Acute Respiratory Syndrome; Malaria Unknown

Small molecule

Approved

Unknown

Carcinoma, Intraductal, Noninfiltrating; Gliosarcoma; Neoplasms; Pancreatic Neoplasms; Severe Dengue; Small Cell Lung Carcinoma; Acquired Immunodeficiency Syndrome; Anemia, Sickle Cell; Brain Diseases; Breast Neoplasms; HIV Infections; Influenza, Human; Lupus Erythematosus, Systemic; Multiple Myeloma; Arthritis, Rheumatoid; Glioblastoma; Malaria, Falciparum; Malaria, Vivax; Pregnancy; Severe Acute Respiratory Syndrome; Malaria

Unknown


Small molecule Approved OTHER ORAL Adenocarcinoma of Lung; Adenomyosis; Aging; Anemia, Sickle Cell; Digestive System Diseases; Fatigue; Fractures, Bone; Head and Neck Neoplasms; Herpes Simplex; Hypertriglyceridemia; Inflammation; Leukemia, Hairy Cell; Leukoplakia, Oral; Liver Diseases, Alcoholic; Neuralgia, Postherpetic; Peripheral Vascular Diseases; Sleep Initiation and Maintenance Disorders; Ulcer; Acute Lung Injury; Adenoma; Barrett Esophagus; Blood Coagulation Disorders; Carotid Stenosis; Depressive Disorder; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Disseminated Intravascular Coagulation; Duodenal Ulcer; Endometrial Neoplasms; Glioblastoma; HIV Infections; Hypercholesterolemia; Hypertension, Pulmonary; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lupus Erythematosus, Systemic; Melanoma; Metabolic Syndrome; Mouth Neoplasms; Nasopharyngeal Carcinoma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Periodontitis; Placental Insufficiency; Pneumonia, Viral; Pregnancy; Prostatic Neoplasms; Purpura, Thrombocytopenic, Idiopathic; Purpura, Thrombotic Thrombocytopenic; Rectal Neoplasms; Respiratory Distress Syndrome; Respiratory Insufficiency; Respiratory Tract Diseases; Sepsis; Tension-Type Headache; Tobacco Use Disorder; Tuberculosis; Uterine Cervical Neoplasms; Venous Thrombosis; Vitamin D Deficiency; Abortion, Habitual; Acute Chest Syndrome; Acute Coronary Syndrome; Adenomatous Polyposis Coli; Angina, Stable; Aortic Valve Stenosis; Asthma; Asthma, Aspirin-Induced; Atherosclerosis; Atrial Fibrillation; Bipolar Disorder; Blindness; Brain Infarction; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Cataract; Cerebral Infarction; Cerebrovascular Disorders; Colitis, Ulcerative; Colonic Neoplasms; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Esophageal Neoplasms; Fetal Growth Retardation; Gastrointestinal Hemorrhage; Heart Diseases; Heart Failure; Hemorrhage; Hip Fractures; Hypertension; Infertility; Influenza, Human; Intracranial Aneurysm; Intracranial Arteriosclerosis; Ischemia; Ischemic Attack, Transient; Ischemic Stroke; Lipid Metabolism Disorders; Low Back Pain; Macular Degeneration; Meningitis; Mucocutaneous Lymph Node Syndrome; Multiple Myeloma; Multiple Sclerosis; Myocardial Ischemia; Non-ST Elevated Myocardial Infarction; Osteoarthritis; Osteonecrosis; Peptic Ulcer; Peripheral Arterial Disease; Pharyngitis; Pneumonia; Polycythemia Vera; Pre-Eclampsia; Prostatic Neoplasms, Castration-Resistant; Psychotic Disorders; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Retinal Artery Occlusion; Retinal Vein Occlusion; Rheumatic Heart Disease; Schizophrenia; Severe Acute Respiratory Syndrome; ST Elevation Myocardial Infarction; Stomach Neoplasms; Stomach Ulcer; Thrombocythemia, Essential; Thrombophilia; Varicose Ulcer; Vascular Diseases; Venous Thromboembolism; Wounds and Injuries; Arthritis; Back Pain; Common Cold; Coronary Artery Disease; Dysmenorrhea; Fever; Headache; Migraine Disorders; Muscle Cramp; Myalgia; Myocardial Infarction; Pain; Spasm; Stroke; Thrombosis; Toothache Cyclooxygenase inhibitor

Small molecule

Approved

OTHER

ORAL

Adenocarcinoma of Lung; Adenomyosis; Aging; Anemia, Sickle Cell; Digestive System Diseases; Fatigue; Fractures, Bone; Head and Neck Neoplasms; Herpes Simplex; Hypertriglyceridemia; Inflammation; Leukemia, Hairy Cell; Leukoplakia, Oral; Liver Diseases, Alcoholic; Neuralgia, Postherpetic; Peripheral Vascular Diseases; Sleep Initiation and Maintenance Disorders; Ulcer; Acute Lung Injury; Adenoma; Barrett Esophagus; Blood Coagulation Disorders; Carotid Stenosis; Depressive Disorder; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Disseminated Intravascular Coagulation; Duodenal Ulcer; Endometrial Neoplasms; Glioblastoma; HIV Infections; Hypercholesterolemia; Hypertension, Pulmonary; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lupus Erythematosus, Systemic; Melanoma; Metabolic Syndrome; Mouth Neoplasms; Nasopharyngeal Carcinoma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Periodontitis; Placental Insufficiency; Pneumonia, Viral; Pregnancy; Prostatic Neoplasms; Purpura, Thrombocytopenic, Idiopathic; Purpura, Thrombotic Thrombocytopenic; Rectal Neoplasms; Respiratory Distress Syndrome; Respiratory Insufficiency; Respiratory Tract Diseases; Sepsis; Tension-Type Headache; Tobacco Use Disorder; Tuberculosis; Uterine Cervical Neoplasms; Venous Thrombosis; Vitamin D Deficiency; Abortion, Habitual; Acute Chest Syndrome; Acute Coronary Syndrome; Adenomatous Polyposis Coli; Angina, Stable; Aortic Valve Stenosis; Asthma; Asthma, Aspirin-Induced; Atherosclerosis; Atrial Fibrillation; Bipolar Disorder; Blindness; Brain Infarction; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Cataract; Cerebral Infarction; Cerebrovascular Disorders; Colitis, Ulcerative; Colonic Neoplasms; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Esophageal Neoplasms; Fetal Growth Retardation; Gastrointestinal Hemorrhage; Heart Diseases; Heart Failure; Hemorrhage; Hip Fractures; Hypertension; Infertility; Influenza, Human; Intracranial Aneurysm; Intracranial Arteriosclerosis; Ischemia; Ischemic Attack, Transient; Ischemic Stroke; Lipid Metabolism Disorders; Low Back Pain; Macular Degeneration; Meningitis; Mucocutaneous Lymph Node Syndrome; Multiple Myeloma; Multiple Sclerosis; Myocardial Ischemia; Non-ST Elevated Myocardial Infarction; Osteoarthritis; Osteonecrosis; Peptic Ulcer; Peripheral Arterial Disease; Pharyngitis; Pneumonia; Polycythemia Vera; Pre-Eclampsia; Prostatic Neoplasms, Castration-Resistant; Psychotic Disorders; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Retinal Artery Occlusion; Retinal Vein Occlusion; Rheumatic Heart Disease; Schizophrenia; Severe Acute Respiratory Syndrome; ST Elevation Myocardial Infarction; Stomach Neoplasms; Stomach Ulcer; Thrombocythemia, Essential; Thrombophilia; Varicose Ulcer; Vascular Diseases; Venous Thromboembolism; Wounds and Injuries; Arthritis; Back Pain; Common Cold; Coronary Artery Disease; Dysmenorrhea; Fever; Headache; Migraine Disorders; Muscle Cramp; Myalgia; Myocardial Infarction; Pain; Spasm; Stroke; Thrombosis; Toothache

Cyclooxygenase inhibitor


Small molecule Approved OTHER INJECTION; OPHTHALMIC; ORAL; OTIC; TOPICAL Osteomyelitis; Acne Vulgaris; Bacterial Infections; Eye Infections Bacterial 70S ribosome inhibitor


Small molecule Approved OTHER ORAL Gliosarcoma; Dermatomyositis; Glioblastoma; Graves Disease; Polymyositis; Graves Ophthalmopathy; Hyperthyroidism; Thyroid Diseases Thyroid peroxidase inhibitor


Small molecule Approved OTHER INJECTION; ORAL Sunburn; Back Pain; Common Cold; Cough; Fever; Headache; Hypersensitivity; Nasal Obstruction; Pain; Pharyngitis; Rhinitis, Allergic, Seasonal; Sinusitis Histamine H1 receptor antagonist


Small molecule Approved Unknown Unknown Atrial Fibrillation; Death, Sudden, Cardiac; Heart Failure; Myocardial Infarction; Ventricular Fibrillation; Arrhythmias, Cardiac Unknown


Small molecule Approved Unknown Unknown Pain Mu opioid receptor agonist


Small molecule Approved Unknown Unknown Hepatitis B, Chronic; Rhinitis, Allergic, Seasonal; Sunburn; Influenza, Human; Hypersensitivity Unknown


Small molecule Approved Unknown Unknown Unknown Unknown


Small molecule Approved DIABETES DRUGS & ENDOCRINOLOGY; OTHER; RHEUMATOLOGY ORAL Glioblastoma; Hypertension, Pulmonary; Intestinal Obstruction; Leukemia, Myeloid, Acute; Nausea; Osteomyelitis; Paraganglioma; Cholangitis, Sclerosing; Peripheral Nervous System Diseases; Premature Birth; Spondylitis, Ankylosing; Arthritis, Psoriatic; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative Arachidonate 5-lipoxygenase inhibitor

Small molecule

Approved

DIABETES DRUGS & ENDOCRINOLOGY; OTHER; RHEUMATOLOGY

ORAL

Glioblastoma; Hypertension, Pulmonary; Intestinal Obstruction; Leukemia, Myeloid, Acute; Nausea; Osteomyelitis; Paraganglioma; Cholangitis, Sclerosing; Peripheral Nervous System Diseases; Premature Birth; Spondylitis, Ankylosing; Arthritis, Psoriatic; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative

Arachidonate 5-lipoxygenase inhibitor


Small molecule Approved Unknown Unknown Digestive System Diseases Unknown


Small molecule Approved Unknown Unknown Depressive Disorder; Hypotension, Orthostatic; Inflammation; Ischemic Stroke; Obesity; Radiodermatitis; Acute Lung Injury; Brain Injuries; Cognitive Dysfunction; Heart Diseases; Hepatorenal Syndrome; Hernias, Diaphragmatic, Congenital; Hypotension; Sepsis; Shock; Shock, Septic; Stroke; Syndrome; Cardiovascular Diseases Unknown


Small molecule Approved OTHER ORAL Osteomyelitis; Colitis, Ulcerative; Crohn Disease; Tuberculosis, Pulmonary; Tuberculosis Dihydrofolate reductase inhibitor


Small molecule Approved Unknown Unknown Osteomyelitis; Bacterial Infections; Eye Infections; Infections Unknown

Small molecule

Approved

Unknown

Colorectal Neoplasms; Depressive Disorder; Head and Neck Neoplasms; Intervertebral Disc Degeneration; Respiratory Insufficiency; Kidney Neoplasms; Neuralgia; Nutrition Disorders; Opioid-Related Disorders; Pre-Eclampsia; Sinusitis; Spinal Cord Injuries; Toothache; Back Pain; Cancer Pain; Diabetic Neuropathies; Genital Neoplasms, Female; Hypospadias; Joint Diseases; Kidney Calculi; Low Back Pain; Neck Pain; Neoplasms; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Parkinson Disease; Pruritus; Restless Legs Syndrome; Chronic Pain; Pain; Substance-Related Disorders

Mu opioid receptor agonist


Small molecule Approved Unknown Unknown Infections; Loiasis; Elephantiasis, Filarial; Helminthiasis Unknown

Small molecule

Approved

Unknown

Constipation; Hepatitis B, Chronic; Non-alcoholic Fatty Liver Disease; Respiratory Syncytial Virus Infections; Severe Acute Respiratory Syndrome; Depressive Disorder; Depressive Disorder, Major; Migraine Disorders; Amyotrophic Lateral Sclerosis; Atrial Fibrillation; Death, Sudden, Cardiac; Multiple Sclerosis; Myocardial Infarction; Ventricular Fibrillation; Arrhythmias, Cardiac

Unknown


Small molecule Approved OTHER TOPICAL Dandruff; Dermatitis, Seborrheic; Pruritus; Tinea Unknown


Small molecule Approved Unknown Unknown Hypotension, Orthostatic; Orthostatic Intolerance Unknown


Small molecule Approved OTHER INJECTION; ORAL Lung Diseases, Obstructive Phosphodiesterase 3A inhibitor


Small molecule Approved OTHER ORAL Epilepsy Sodium channel alpha subunit blocker