DrugMapper


Display Options: Drug type Therapeutic Area Route of administration Mechanism of Action Indication Status		Total: 92


Small molecule Approved OTHER ORAL Renal Colic; Osteoarthritis, Knee; Tennis Elbow; Arthralgia; Arthritis, Rheumatoid; Eye Diseases; Myalgia; Osteoarthritis; Rheumatic Diseases Cyclooxygenase inhibitor


Small molecule Approved OTHER ORAL Amyotrophic Lateral Sclerosis; Anxiety; Dementia; Depressive Disorder; Schizophrenia; Psychotic Disorders; Tics; Tourette Syndrome Dopamine receptor antagonist


Small molecule Approved OTHER NASAL; ORAL; TRANSDERMAL Aging; Attention Deficit Disorder with Hyperactivity; Cocaine-Related Disorders; Memory Disorders; Sarcoidosis; Schizophrenia; Alcohol Drinking; Carcinoma in Situ; Cognitive Dysfunction; Depressive Disorder; Parkinson Disease; Postoperative Nausea and Vomiting; Sarcoma; Substance-Related Disorders; Wounds and Injuries; Heart Failure; Lung Neoplasms; Marijuana Abuse; Pulmonary Disease, Chronic Obstructive; Severe Acute Respiratory Syndrome; Smoking Cessation; Tuberculosis; Uterine Cervical Neoplasms; Tobacco Use Disorder Neuronal acetylcholine receptor; alpha4/beta2 agonist

Small molecule

Approved

OTHER

NASAL; ORAL; TRANSDERMAL

Aging; Attention Deficit Disorder with Hyperactivity; Cocaine-Related Disorders; Memory Disorders; Sarcoidosis; Schizophrenia; Alcohol Drinking; Carcinoma in Situ; Cognitive Dysfunction; Depressive Disorder; Parkinson Disease; Postoperative Nausea and Vomiting; Sarcoma; Substance-Related Disorders; Wounds and Injuries; Heart Failure; Lung Neoplasms; Marijuana Abuse; Pulmonary Disease, Chronic Obstructive; Severe Acute Respiratory Syndrome; Smoking Cessation; Tuberculosis; Uterine Cervical Neoplasms; Tobacco Use Disorder

Neuronal acetylcholine receptor; alpha4/beta2 agonist


Small molecule Approved OTHER ORAL Cognitive Dysfunction; Joint Diseases; Alcoholism; Anemia, Sickle Cell; Bipolar Disorder; Essential Tremor; Multiple Sclerosis; Schizophrenia; Substance-Related Disorders; Alcohol Drinking; Amyotrophic Lateral Sclerosis; Arthritis, Psoriatic; Chronic Pain; Dementia; HIV Infections; Irritable Bowel Syndrome; Marijuana Abuse; Migraine with Aura; Migraine without Aura; Opioid-Related Disorders; Pain; Sleep Apnea, Obstructive; Stress Disorders, Post-Traumatic; Torticollis; Tourette Syndrome; Trichotillomania; Anorexia Nervosa; Osteoarthritis, Knee; Anorexia; Nausea; Neoplasms; Postoperative Nausea and Vomiting Cannabinoid CB1 receptor agonist

Small molecule

Approved

OTHER

ORAL

Cognitive Dysfunction; Joint Diseases; Alcoholism; Anemia, Sickle Cell; Bipolar Disorder; Essential Tremor; Multiple Sclerosis; Schizophrenia; Substance-Related Disorders; Alcohol Drinking; Amyotrophic Lateral Sclerosis; Arthritis, Psoriatic; Chronic Pain; Dementia; HIV Infections; Irritable Bowel Syndrome; Marijuana Abuse; Migraine with Aura; Migraine without Aura; Opioid-Related Disorders; Pain; Sleep Apnea, Obstructive; Stress Disorders, Post-Traumatic; Torticollis; Tourette Syndrome; Trichotillomania; Anorexia Nervosa; Osteoarthritis, Knee; Anorexia; Nausea; Neoplasms; Postoperative Nausea and Vomiting

Cannabinoid CB1 receptor agonist


Small molecule Approved MUSCULOSKELETAL; OTHER; RHEUMATOLOGY ORAL Kidney Calculi; Renal Colic; Paget Disease, Extramammary; Periodontitis; Bursitis; Inflammation; Low Back Pain; Migraine Disorders; Osteoarthritis, Knee; Postoperative Nausea and Vomiting; Sprains and Strains; Tendinopathy; Wounds and Injuries; Acute Pain; Arthralgia; Arthritis, Rheumatoid; Dysmenorrhea; Myalgia; Osteoarthritis; Pain; Rheumatic Diseases Cyclooxygenase inhibitor

Small molecule

Approved

MUSCULOSKELETAL; OTHER; RHEUMATOLOGY

ORAL

Kidney Calculi; Renal Colic; Paget Disease, Extramammary; Periodontitis; Bursitis; Inflammation; Low Back Pain; Migraine Disorders; Osteoarthritis, Knee; Postoperative Nausea and Vomiting; Sprains and Strains; Tendinopathy; Wounds and Injuries; Acute Pain; Arthralgia; Arthritis, Rheumatoid; Dysmenorrhea; Myalgia; Osteoarthritis; Pain; Rheumatic Diseases

Cyclooxygenase inhibitor


Small molecule Approved OTHER ORAL Anemia; Arthritis, Rheumatoid; Diabetes Mellitus, Type 2; HIV Infections; Mitochondrial Diseases; Low Back Pain; Periodontitis; Pain; Pharyngitis; Arthralgia; Eye Diseases; Miosis; Myalgia; Rheumatic Diseases Cyclooxygenase inhibitor


Small molecule Approved OTHER ORAL Aging; Depressive Disorder; Neoplasms; Periodontitis; Carcinoma; Carcinoma, Basal Cell; Mastodynia; Pulmonary Embolism; Infertility; Osteoarthritis, Hip; Osteoarthritis, Knee; Renal Colic; Spondylitis, Ankylosing; Stomach Ulcer; Toothache; Acute Pain; Arthralgia; Arthritis, Rheumatoid; Cataract; Dysmenorrhea; Eye Diseases; Inflammation; Keratosis, Actinic; Migraine Disorders; Myalgia; Osteoarthritis; Pain; Rheumatic Diseases; Sprains and Strains Cyclooxygenase inhibitor

Small molecule

Approved

OTHER

ORAL

Aging; Depressive Disorder; Neoplasms; Periodontitis; Carcinoma; Carcinoma, Basal Cell; Mastodynia; Pulmonary Embolism; Infertility; Osteoarthritis, Hip; Osteoarthritis, Knee; Renal Colic; Spondylitis, Ankylosing; Stomach Ulcer; Toothache; Acute Pain; Arthralgia; Arthritis, Rheumatoid; Cataract; Dysmenorrhea; Eye Diseases; Inflammation; Keratosis, Actinic; Migraine Disorders; Myalgia; Osteoarthritis; Pain; Rheumatic Diseases; Sprains and Strains

Cyclooxygenase inhibitor


Small molecule Approved CARDIOVASCULAR; OTHER ORAL Cerebrovascular Disorders; Schizophrenia; Intracranial Aneurysm; Cocaine-Related Disorders; Infertility; Neurilemmoma; Stroke; Subarachnoid Hemorrhage; Cardiovascular Diseases Mineralocorticoid receptor antagonist


Small molecule Approved OTHER ORAL Infections; Abortion, Incomplete; Clostridium Infections; Muscle Cramp; Premature Birth; Abortion, Spontaneous; Leiomyoma; Menorrhagia; Obesity; Pain; Postpartum Hemorrhage; Pre-Eclampsia; Pregnancy; Spondylitis, Ankylosing; Uterine Diseases; Duodenal Ulcer; Gastroesophageal Reflux; Hemorrhage; Osteoarthritis; Peptic Ulcer; Stomach Ulcer Prostanoid EP3 receptor agonist

Small molecule

Approved

OTHER

ORAL

Infections; Abortion, Incomplete; Clostridium Infections; Muscle Cramp; Premature Birth; Abortion, Spontaneous; Leiomyoma; Menorrhagia; Obesity; Pain; Postpartum Hemorrhage; Pre-Eclampsia; Pregnancy; Spondylitis, Ankylosing; Uterine Diseases; Duodenal Ulcer; Gastroesophageal Reflux; Hemorrhage; Osteoarthritis; Peptic Ulcer; Stomach Ulcer

Prostanoid EP3 receptor agonist


Small molecule Approved OTHER ORAL Anxiety; Bipolar Disorder; Dementia; Depressive Disorder; Developmental Disabilities; Intellectual Disability; Psychotic Disorders; Schizophrenia Dopamine D2 receptor antagonist


Small molecule Approved OTHER ORAL Sleep Initiation and Maintenance Disorders GABA-A receptor; anion channel positive allosteric modulator


Small molecule Approved OTHER ORAL Arthritis, Rheumatoid; Osteoarthritis; Rheumatic Diseases Cyclooxygenase-2 inhibitor


Small molecule Approved OTHER INJECTION Anxiety; Fragile X Syndrome; Idiopathic Hypersomnia; Narcolepsy; Parkinson Disease; Sleep Initiation and Maintenance Disorders; Alcoholism; Obsessive-Compulsive Disorder; Substance-Related Disorders GABA-A receptor; anion channel allosteric antagonist


Small molecule Approved DIABETES DRUGS & ENDOCRINOLOGY; MUSCULOSKELETAL; OTHER; RHEUMATOLOGY ORAL Lecithin Cholesterol Acyltransferase Deficiency; Carcinoma, Hepatocellular; Pancreatic Neoplasms; Colorectal Neoplasms; Muscular Diseases; Pain; Sprains and Strains; Acute Pain; Arthritis, Juvenile; Arthritis, Rheumatoid; Osteoarthritis; Rheumatic Diseases Cyclooxygenase-2 inhibitor


Small molecule Approved EMERGENCY MEDICINE; GASTROINTESTINAL; OTHER INJECTION; ORAL Dyspnea; Brain Diseases; Brain Injuries; Lecithin Cholesterol Acyltransferase Deficiency; Neuralgia; Opioid-Related Disorders; Amphetamine-Related Disorders; Breast Neoplasms; Cholecystitis; Cocaine-Related Disorders; Glioma; Hallucinations; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Obsessive-Compulsive Disorder; Pancreatic Neoplasms; Sarcoma; Tobacco Use Disorder; Tonsillitis; Alcoholism; Gastroenteritis; Genital Neoplasms, Female; HIV Infections; Hypotension; Irritable Bowel Syndrome; Pain; Schizophrenia; Uterine Cervical Neoplasms; Vomiting; Nausea; Neoplasms; Postoperative Nausea and Vomiting Serotonin 3a (5-HT3a) receptor antagonist

Small molecule

Approved

EMERGENCY MEDICINE; GASTROINTESTINAL; OTHER

INJECTION; ORAL

Dyspnea; Brain Diseases; Brain Injuries; Lecithin Cholesterol Acyltransferase Deficiency; Neuralgia; Opioid-Related Disorders; Amphetamine-Related Disorders; Breast Neoplasms; Cholecystitis; Cocaine-Related Disorders; Glioma; Hallucinations; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Obsessive-Compulsive Disorder; Pancreatic Neoplasms; Sarcoma; Tobacco Use Disorder; Tonsillitis; Alcoholism; Gastroenteritis; Genital Neoplasms, Female; HIV Infections; Hypotension; Irritable Bowel Syndrome; Pain; Schizophrenia; Uterine Cervical Neoplasms; Vomiting; Nausea; Neoplasms; Postoperative Nausea and Vomiting

Serotonin 3a (5-HT3a) receptor antagonist


Small molecule Approved OTHER ORAL Arthritis, Juvenile; Arthritis, Rheumatoid; Osteoarthritis; Rheumatic Diseases Cyclooxygenase inhibitor


Small molecule Approved IMMUNE SYSTEM; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS ORAL Alopecia; Child Development Disorders, Pervasive; Premature Birth; Psychotic Disorders; Abortion, Spontaneous; Anemia, Sickle Cell; Breast Neoplasms; Hyperemesis Gravidarum; Intervertebral Disc Displacement; Low Back Pain; Marijuana Abuse; Mucositis; Multiple Sclerosis; Neoplasms; Opioid-Related Disorders; Paget Disease, Extramammary; Postoperative Complications; Prostatic Neoplasms, Castration-Resistant; Rotator Cuff Injuries; Substance-Related Disorders; Substance Withdrawal Syndrome; Tinnitus; Tobacco Use Disorder; Urinary Bladder Neoplasms; Wounds and Injuries; Alcohol Drinking; Alcoholism; Anxiety; Azoospermia; Carpal Tunnel Syndrome; Chronic Pain; Delirium; Dementia; Depressive Disorder; Diabetic Neuropathies; Dyspepsia; Epilepsies, Partial; Fibromyalgia; Head and Neck Neoplasms; Herpes Zoster; Hot Flashes; Intervertebral Disc Degeneration; Liver Cirrhosis; Neuralgia; Oropharyngeal Neoplasms; Pain; Pelvic Organ Prolapse; Postoperative Nausea and Vomiting; Pruritus; Schizophrenia; Scoliosis; Sleep Initiation and Maintenance Disorders; Tremor; Vomiting; Epilepsy; Neuralgia, Postherpetic; Restless Legs Syndrome; Seizures Voltage-gated calcium channel modulator

Small molecule

Approved

IMMUNE SYSTEM; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS

ORAL

Alopecia; Child Development Disorders, Pervasive; Premature Birth; Psychotic Disorders; Abortion, Spontaneous; Anemia, Sickle Cell; Breast Neoplasms; Hyperemesis Gravidarum; Intervertebral Disc Displacement; Low Back Pain; Marijuana Abuse; Mucositis; Multiple Sclerosis; Neoplasms; Opioid-Related Disorders; Paget Disease, Extramammary; Postoperative Complications; Prostatic Neoplasms, Castration-Resistant; Rotator Cuff Injuries; Substance-Related Disorders; Substance Withdrawal Syndrome; Tinnitus; Tobacco Use Disorder; Urinary Bladder Neoplasms; Wounds and Injuries; Alcohol Drinking; Alcoholism; Anxiety; Azoospermia; Carpal Tunnel Syndrome; Chronic Pain; Delirium; Dementia; Depressive Disorder; Diabetic Neuropathies; Dyspepsia; Epilepsies, Partial; Fibromyalgia; Head and Neck Neoplasms; Herpes Zoster; Hot Flashes; Intervertebral Disc Degeneration; Liver Cirrhosis; Neuralgia; Oropharyngeal Neoplasms; Pain; Pelvic Organ Prolapse; Postoperative Nausea and Vomiting; Pruritus; Schizophrenia; Scoliosis; Sleep Initiation and Maintenance Disorders; Tremor; Vomiting; Epilepsy; Neuralgia, Postherpetic; Restless Legs Syndrome; Seizures

Voltage-gated calcium channel modulator


Small molecule Approved OTHER ORAL Bipolar Disorder; Anemia; Epilepsy; Seizures Glutamate [NMDA] receptor antagonist


Small molecule Approved OTHER INTRAMUSCULAR; ORAL; SUBCUTANEOUS Opioid-Related Disorders; Substance-Related Disorders; Dyskinesia, Drug-Induced; Huntington Disease; Lecithin Cholesterol Acyltransferase Deficiency; Schizotypal Personality Disorder; Amphetamine-Related Disorders; Child Development Disorders, Pervasive; Cocaine-Related Disorders; Stress Disorders, Post-Traumatic; Tourette Syndrome; Alzheimer Disease; Anxiety; Asperger Syndrome; Attention Deficit and Disruptive Behavior Disorders; Conduct Disorder; Dementia; Dementia, Vascular; Depressive Disorder; Depressive Disorder, Major; Developmental Disabilities; Intellectual Disability; Neurodevelopmental Disorders; Rett Syndrome; Aggression; Autistic Disorder; Bipolar Disorder; Psychotic Disorders; Schizophrenia Dopamine D2 receptor antagonist

Small molecule

Approved

OTHER

INTRAMUSCULAR; ORAL; SUBCUTANEOUS

Opioid-Related Disorders; Substance-Related Disorders; Dyskinesia, Drug-Induced; Huntington Disease; Lecithin Cholesterol Acyltransferase Deficiency; Schizotypal Personality Disorder; Amphetamine-Related Disorders; Child Development Disorders, Pervasive; Cocaine-Related Disorders; Stress Disorders, Post-Traumatic; Tourette Syndrome; Alzheimer Disease; Anxiety; Asperger Syndrome; Attention Deficit and Disruptive Behavior Disorders; Conduct Disorder; Dementia; Dementia, Vascular; Depressive Disorder; Depressive Disorder, Major; Developmental Disabilities; Intellectual Disability; Neurodevelopmental Disorders; Rett Syndrome; Aggression; Autistic Disorder; Bipolar Disorder; Psychotic Disorders; Schizophrenia

Dopamine D2 receptor antagonist


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER ORAL HIV Infections; Lecithin Cholesterol Acyltransferase Deficiency; Mental Disorders; Alcoholism; Cocaine-Related Disorders; Cognitive Dysfunction; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Neuralgia, Postherpetic; Neurofibromatosis 1; Opioid-Related Disorders; Substance-Related Disorders; Anxiety; Dementia; Epilepsy, Absence; Feeding and Eating Disorders; Mood Disorders; Obesity; Pain; Peripheral Nervous System Diseases; Schizophrenia; Bipolar Disorder; Depressive Disorder; Epilepsies, Partial; Epilepsy; Epilepsy, Tonic-Clonic; Lennox Gastaut Syndrome; Seizures Sodium channel alpha subunit blocker

Small molecule

Approved

NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

ORAL

HIV Infections; Lecithin Cholesterol Acyltransferase Deficiency; Mental Disorders; Alcoholism; Cocaine-Related Disorders; Cognitive Dysfunction; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Neuralgia, Postherpetic; Neurofibromatosis 1; Opioid-Related Disorders; Substance-Related Disorders; Anxiety; Dementia; Epilepsy, Absence; Feeding and Eating Disorders; Mood Disorders; Obesity; Pain; Peripheral Nervous System Diseases; Schizophrenia; Bipolar Disorder; Depressive Disorder; Epilepsies, Partial; Epilepsy; Epilepsy, Tonic-Clonic; Lennox Gastaut Syndrome; Seizures

Sodium channel alpha subunit blocker


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER ORAL Breast Neoplasms; Stress Disorders, Post-Traumatic; Alzheimer Disease; Bipolar Disorder; Cerebellar Ataxia; Child Development Disorders, Pervasive; Depressive Disorder; Depressive Disorder, Major; Melanoma; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Muscular Atrophy, Spinal; Obsessive-Compulsive Disorder; Peripheral Nervous System Diseases; Spinal Cord Injuries; Huntington Disease; Multiple System Atrophy; Spinal Cord Diseases; Spinocerebellar Ataxias; Supranuclear Palsy, Progressive; Amyotrophic Lateral Sclerosis Sodium channel alpha subunit blocker

Small molecule

Approved

NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

ORAL

Breast Neoplasms; Stress Disorders, Post-Traumatic; Alzheimer Disease; Bipolar Disorder; Cerebellar Ataxia; Child Development Disorders, Pervasive; Depressive Disorder; Depressive Disorder, Major; Melanoma; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Muscular Atrophy, Spinal; Obsessive-Compulsive Disorder; Peripheral Nervous System Diseases; Spinal Cord Injuries; Huntington Disease; Multiple System Atrophy; Spinal Cord Diseases; Spinocerebellar Ataxias; Supranuclear Palsy, Progressive; Amyotrophic Lateral Sclerosis

Sodium channel alpha subunit blocker


Small molecule Approved DIABETES DRUGS & ENDOCRINOLOGY; OTHER ORAL Postoperative Nausea and Vomiting; Sleep Apnea, Obstructive; Alcoholism; Amphetamine-Related Disorders; Cocaine-Related Disorders; Fibromyalgia; Glioma; Substance-Related Disorders; Weight Loss; Anorexia; Anxiety; Cachexia; Child Development Disorders, Pervasive; Dementia; Heroin Dependence; Nausea; Schizophrenia; Depressive Disorder; Depressive Disorder, Major; Sleep Initiation and Maintenance Disorders Adrenergic receptor alpha-2 antagonist

Small molecule

Approved

DIABETES DRUGS & ENDOCRINOLOGY; OTHER

ORAL

Postoperative Nausea and Vomiting; Sleep Apnea, Obstructive; Alcoholism; Amphetamine-Related Disorders; Cocaine-Related Disorders; Fibromyalgia; Glioma; Substance-Related Disorders; Weight Loss; Anorexia; Anxiety; Cachexia; Child Development Disorders, Pervasive; Dementia; Heroin Dependence; Nausea; Schizophrenia; Depressive Disorder; Depressive Disorder, Major; Sleep Initiation and Maintenance Disorders

Adrenergic receptor alpha-2 antagonist


Small molecule Approved OTHER INTRAMUSCULAR; ORAL Dyskinesia, Drug-Induced; Lecithin Cholesterol Acyltransferase Deficiency; Mood Disorders; Weight Loss; Amyotrophic Lateral Sclerosis; Anorexia Nervosa; Autistic Disorder; Delirium; Vomiting; Alcoholism; Anxiety; Borderline Personality Disorder; Dementia; Depressive Disorder; Depressive Disorder, Treatment-Resistant; Developmental Disabilities; Feeding and Eating Disorders; Gambling; Genital Neoplasms, Female; Huntington Disease; Intellectual Disability; Nausea; Neoplasms; Postoperative Nausea and Vomiting; Weight Gain; Bipolar Disorder; Depressive Disorder, Major; Psychomotor Agitation; Psychotic Disorders; Schizophrenia D2-like dopamine receptor antagonist

Small molecule

Approved

OTHER

INTRAMUSCULAR; ORAL

Dyskinesia, Drug-Induced; Lecithin Cholesterol Acyltransferase Deficiency; Mood Disorders; Weight Loss; Amyotrophic Lateral Sclerosis; Anorexia Nervosa; Autistic Disorder; Delirium; Vomiting; Alcoholism; Anxiety; Borderline Personality Disorder; Dementia; Depressive Disorder; Depressive Disorder, Treatment-Resistant; Developmental Disabilities; Feeding and Eating Disorders; Gambling; Genital Neoplasms, Female; Huntington Disease; Intellectual Disability; Nausea; Neoplasms; Postoperative Nausea and Vomiting; Weight Gain; Bipolar Disorder; Depressive Disorder, Major; Psychomotor Agitation; Psychotic Disorders; Schizophrenia

D2-like dopamine receptor antagonist


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS ORAL Feeding and Eating Disorders; Bulimia Nervosa; Cognitive Dysfunction; Hernias, Diaphragmatic, Congenital; Liver Diseases; Alcohol Drinking; Amphetamine-Related Disorders; Brain Ischemia; Diabetes Mellitus; Marijuana Abuse; Multiple Sclerosis; Parkinson Disease; Sciatica; Stress Disorders, Post-Traumatic; Alcoholism; Anxiety; Bipolar Disorder; Bulimia; Cocaine-Related Disorders; Dementia; Depressive Disorder; Diabetes Mellitus, Type 2; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Essential Tremor; Gambling; Headache; Hyperlipidemias; Hypertension; Hypertriglyceridemia; Metabolic Syndrome; Obesity; Obsessive-Compulsive Disorder; Pain; Prader-Willi Syndrome; Schizophrenia; Smoking Cessation; Tobacco Use Disorder; Tourette Syndrome; Epilepsy; Lennox Gastaut Syndrome; Migraine Disorders; Seizures Carbonic anhydrase II inhibitor

Small molecule

Approved

NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS

ORAL

Feeding and Eating Disorders; Bulimia Nervosa; Cognitive Dysfunction; Hernias, Diaphragmatic, Congenital; Liver Diseases; Alcohol Drinking; Amphetamine-Related Disorders; Brain Ischemia; Diabetes Mellitus; Marijuana Abuse; Multiple Sclerosis; Parkinson Disease; Sciatica; Stress Disorders, Post-Traumatic; Alcoholism; Anxiety; Bipolar Disorder; Bulimia; Cocaine-Related Disorders; Dementia; Depressive Disorder; Diabetes Mellitus, Type 2; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Essential Tremor; Gambling; Headache; Hyperlipidemias; Hypertension; Hypertriglyceridemia; Metabolic Syndrome; Obesity; Obsessive-Compulsive Disorder; Pain; Prader-Willi Syndrome; Schizophrenia; Smoking Cessation; Tobacco Use Disorder; Tourette Syndrome; Epilepsy; Lennox Gastaut Syndrome; Migraine Disorders; Seizures

Carbonic anhydrase II inhibitor


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER SUBCUTANEOUS Amyotrophic Lateral Sclerosis; Crohn Disease; Macular Degeneration; Multiple Sclerosis, Chronic Progressive; Rett Syndrome; Glaucoma, Angle-Closure; Multiple Sclerosis, Relapsing-Remitting; Optic Neuritis; Multiple Sclerosis Unknown


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER NASAL; ORAL Migraine Disorders Serotonin 1b (5-HT1b) receptor agonist

Small molecule

Approved

OTHER

ORAL

Cognitive Dysfunction; Hypotension, Orthostatic; Melanoma; Psychotic Disorders; Sleep Apnea Syndromes; Sleep Initiation and Maintenance Disorders; Tinnitus; Tobacco Use Disorder; Alcoholism; Amphetamine-Related Disorders; Deglutition Disorders; Depressive Disorder; Opioid-Related Disorders; Ovarian Neoplasms; Parkinson Disease; Schizophrenia; Stress Disorders, Post-Traumatic; Substance-Related Disorders; Alzheimer Disease; Brain Neoplasms; Cocaine-Related Disorders; Depressive Disorder, Major; Fatigue; Multiple Sclerosis; Narcolepsy; Postpoliomyelitis Syndrome; Sarcoma, Ewing; Sleep Apnea, Obstructive; Sleep Wake Disorders; Stroke; Attention Deficit Disorder with Hyperactivity

Dopamine transporter inhibitor

Small molecule

Approved

OTHER

ORAL

Depressive Disorder, Major; Obesity; Breast Carcinoma In Situ; Carcinoma, Hepatocellular; Hepatolenticular Degeneration; Hypotension, Orthostatic; Inflammation; Keratosis, Actinic; Mouth Neoplasms; Myeloproliferative Disorders; Neuroblastoma; Tuberculosis; Uterine Cervical Neoplasms; Amyotrophic Lateral Sclerosis; Back Pain; Brain Neoplasms; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Cervical Intraepithelial Neoplasia; Esophageal Neoplasms; Facial Pain; Glioblastoma; Glioma; Graves Ophthalmopathy; Lymphangioleiomyomatosis; Medulloblastoma; Melanoma; Multiple Myeloma; Muscular Atrophy, Spinal; Neuralgia; Neurofibromatosis 1; Obsessive-Compulsive Disorder; Ovarian Neoplasms; Papilloma; Papillomavirus Infections; Paraproteinemias; Peritoneal Neoplasms; Pre-Eclampsia; Prostatic Hyperplasia; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rotator Cuff Injuries; Sarcoma; Schizophrenia; Severe Acute Respiratory Syndrome; Squamous Cell Carcinoma of Head and Neck; Squamous Intraepithelial Lesions; Stomatitis; Temporomandibular Joint Disorders; Tonsillitis; Toothache; Urinary Bladder Neoplasms; Uterine Neoplasms; Adenoma; Alzheimer Disease; Bipolar Disorder; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Chronic Pain; Colonic Neoplasms; Colorectal Neoplasms; Depression, Postpartum; Depressive Disorder; Gout; Hand-Foot Syndrome; Head and Neck Neoplasms; Hypertension; Influenza, Human; Liver Neoplasms; Low Back Pain; Lung Neoplasms; Macular Degeneration; Memory Disorders; Nasopharyngeal Neoplasms; Osteoarthritis, Hip; Osteoarthritis, Knee; Pancreatic Neoplasms; Pharyngitis; Rectal Neoplasms; Tobacco Use Disorder; Wounds and Injuries; Acute Pain; Adenomatous Polyposis Coli; Arthritis, Juvenile; Arthritis, Rheumatoid; Dysmenorrhea; Hemorrhage; Migraine Disorders; Neoplasms; Osteoarthritis; Pain; Peptic Ulcer; Rheumatic Diseases; Spondylitis; Spondylitis, Ankylosing; Stroke

Cyclooxygenase-2 inhibitor


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER ORAL Cocaine-Related Disorders; Neuroblastoma; Alcoholism; Brain Injuries; Gambling; Obsessive-Compulsive Disorder; Pick Disease of the Brain; Schizophrenia; Tobacco Use Disorder; Liver Failure; Parkinson Disease Catechol O-methyltransferase inhibitor

Small molecule

Approved

NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

INTRAVENOUS; ORAL

Aphasia; Canavan Disease; Essential Tremor; Stroke; Alzheimer Disease; Anemia, Sickle Cell; Bipolar Disorder; Brain Neoplasms; Cocaine-Related Disorders; Cognitive Dysfunction; Dyskinesia, Drug-Induced; Epilepsy, Absence; Epilepsy, Reflex; Glioblastoma; Glioma; Leukemia, Myeloid, Acute; Neuralgia, Postherpetic; Neuroblastoma; Obsessive-Compulsive Disorder; Opioid-Related Disorders; Parkinson Disease; Polyneuropathies; Psychotic Disorders; Restless Legs Syndrome; Stress Disorders, Post-Traumatic; Torticollis; Alcoholism; Anxiety; Dementia; Depressive Disorder; Epilepsies, Partial; Movement Disorders; Panic Disorder; Schizophrenia; Status Epilepticus; Subarachnoid Hemorrhage; Substance Withdrawal Syndrome; Epilepsy; Epilepsy, Tonic-Clonic; Seizures

Synaptic vesicle glycoprotein 2A modulator


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER ORAL Amphetamine-Related Disorders; Gastrointestinal Stromal Tumors; Epilepsy; Obesity; Cocaine-Related Disorders; Parkinson Disease Catechol O-methyltransferase inhibitor


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER ORAL Anxiety; Dementia; Depressive Disorder; Schizophrenia; Sleep Initiation and Maintenance Disorders GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator

Small molecule

Approved

NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

TRANSDERMAL

Amphetamine-Related Disorders; Cocaine-Related Disorders; Down Syndrome; Substance-Related Disorders; Anxiety; Brain Injuries; Cognitive Dysfunction; Delirium; Dementia, Vascular; Depressive Disorder; Neurobehavioral Manifestations; Schizophrenia; Supranuclear Palsy, Progressive; Alzheimer Disease; Dementia; Parkinson Disease

Cholinesterases; ACHE & BCHE inhibitor


Small molecule Approved MUSCULOSKELETAL; OTHER ORAL Lupus Erythematosus, Systemic; Dysmenorrhea; Pharyngitis; Toothache; Low Back Pain; Migraine Disorders; Pain; Prostatic Neoplasms; Shoulder Pain; Spondylitis, Ankylosing; Tuberculosis; Arthritis, Juvenile; Arthritis, Rheumatoid; Osteoarthritis; Rheumatic Diseases Cyclooxygenase-2 inhibitor

Small molecule

Approved

NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

ORAL

Cocaine-Related Disorders; Hearing Loss, Noise-Induced; Tobacco Use Disorder; Essential Tremor; Hearing Loss; Migraine Disorders; Obesity; Parkinson Disease; Alcoholism; Epilepsy, Complex Partial; Feeding and Eating Disorders; Psychotic Disorders; Schizophrenia; Smoking Cessation; Weight Gain; Epilepsy; Seizures

Sodium channel alpha subunit blocker