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Total: 10647
Enzyme
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER; UROLOGY AND KIDNEY
INTRAVENOUS
Fabry Disease
Globotriosylceramide hydrolytic enzyme
Enzyme
Approved
RESPIRATORY
UNKNOWN
Mucopolysaccharidosis I; Mucopolysaccharidoses
Dermatan sulfate hydrolytic enzyme
Small molecule
Approved
OTHER
TOPICAL
Candidiasis, Vulvovaginal; Tinea Pedis
Cytochrome P450 51 inhibitor
Small molecule
Approved
OTHER
ORAL
Cystic Fibrosis; HIV Infections; Spastic Paraplegia, Hereditary; Gangliosidoses, GM2; Glycogen Storage Disease; Glycogen Storage Disease Type II; Niemann-Pick Disease, Type C; Sandhoff Disease; Gaucher Disease
Ceramide glucosyltransferase inhibitor
Small molecule
Approved
CANCER; GASTROINTESTINAL; OTHER
INTRAVENOUS; ORAL
Glioblastoma; Heroin Dependence; HIV Infections; Opioid-Related Disorders; Alcoholism; Cocaine-Related Disorders; Gastroparesis; Leukemia, Myeloid, Acute; Marijuana Abuse; Pain; Pruritus; Severe Acute Respiratory Syndrome; Carcinoma, Non-Small-Cell Lung; Depressive Disorder, Major; Multiple Myeloma; Neoplasms, Germ Cell and Embryonal; Vomiting; Nausea; Neoplasms; Postoperative Nausea and Vomiting
Neurokinin 1 receptor antagonist
Small molecule
Approved
Unknown
Unknown
Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Eye Manifestations; Hypersensitivity
Unknown
Small molecule
Approved
Unknown
Unknown
Melanoma; Vomiting; Brain Neoplasms; Breast Neoplasms; Glioma; Multiple Myeloma; Stomach Neoplasms; Neoplasms; Postoperative Nausea and Vomiting; Strabismus; Nausea
Unknown
Protein
Approved
Unknown
Unknown
Thrombosis; Venous Thrombosis
Thrombin inhibitor
Small molecule
Approved
Unknown
Unknown
Reperfusion Injury; Cystic Fibrosis; Prostatic Hyperplasia; Raynaud Disease; Tinnitus; Urinary Bladder, Overactive; Hypertension, Pulmonary; Erectile Dysfunction
Unknown
Small molecule
Approved
CANCER
INJECTION; INTRAVENOUS; SUBCUTANEOUS; UNKNOWN
Myeloproliferative Disorders; Anemia, Refractory, with Excess of Blasts; Astrocytoma; Burkitt Lymphoma; Carcinoma, Medullary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Fallopian Tube Neoplasms; Glioblastoma; Immunoblastic Lymphadenopathy; Leukemia-Lymphoma, Adult T-Cell; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Muscular Dystrophies; Mycosis Fungoides; Neuroblastoma; Oligodendroglioma; Peritoneal Neoplasms; Sezary Syndrome; Smoldering Multiple Myeloma; Uremia; Adenocarcinoma, Bronchiolo-Alveolar; Adenocarcinoma, Follicular; Adenocarcinoma of Lung; Breast Neoplasms; Bronchiolitis Obliterans; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Castleman Disease; Central Nervous System Neoplasms; Colorectal Neoplasms; Encephalitis, Japanese; Esophageal Neoplasms; Glioma; Gliosarcoma; Graft vs Host Disease; Head and Neck Neoplasms; Hematologic Neoplasms; Hodgkin Disease; Immune System Diseases; Kidney Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Plasma Cell; Leukemia, Promyelocytic, Acute; Lung Neoplasms; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Lymphoproliferative Disorders; Melanoma; Mesothelioma; Myelodysplastic Syndromes; Nasopharyngeal Neoplasms; Neuromyelitis Optica; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Red-Cell Aplasia, Pure; Sarcoma; Stomach Neoplasms; Thyroid Neoplasms; Ureteral Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Amyloidosis; Amyloidosis, Familial; Cholangiocarcinoma; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Plasmacytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Renal Insufficiency, Chronic; Sarcoma, Myeloid; Waldenstrom Macroglobulinemia; Lymphoma, Mantle-Cell; Multiple Myeloma; Neoplasms
26S proteosome inhibitor
Small molecule
Approved
Unknown
Unknown
Hypersensitivity
Unknown
Antibody
Approved
Unknown
Unknown
Arthritis, Psoriatic; Hidradenitis Suppurativa; Macular Degeneration; Renal Insufficiency, Chronic; Alopecia; Arthritis, Rheumatoid; Dermatitis, Atopic; Diabetes Mellitus, Type 1; Sjogren's Syndrome; Psoriasis; Immune System Diseases
Integrin alpha-L/beta-2 (LFA-1) inhibitor
Small molecule
Approved
OTHER
ORAL
Angioedema; Conjunctivitis, Allergic; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Rhinitis, Vasomotor; Urticaria
Histamine H1 receptor antagonist
Small molecule
Approved
OTHER
ORAL
Unknown
Voltage-gated L-type calcium channel blocker
Protein
Approved
CANCER
INTRAMUSCULAR
Prostatic Neoplasms, Castration-Resistant; Neoplasms
Gonadotropin-releasing hormone receptor antagonist
Small molecule
Approved
Unknown
Unknown
Abdominal Pain; Bone Neoplasms; Breast Neoplasms; Hematologic Neoplasms; Multiple Myeloma; Neoplasm Metastasis; Osteonecrosis; Osteoporosis; Osteoporosis, Postmenopausal; Pain; Bone Diseases
Unknown
Small molecule
Approved
NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; RESPIRATORY
ORAL
Head and Neck Neoplasms; Muscular Dystrophies; Astrocytoma; Glioblastoma; Heart Failure; Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cushing Syndrome; Dementia, Vascular; Diabetes Mellitus, Type 2; Eisenmenger Complex; Essential Hypertension; Gastroparesis; Hypertension; Multiple Myeloma; Obesity; Priapism; Scleroderma, Systemic; Stroke; Glucose Intolerance; Heart Defects, Congenital; Insulin Resistance; Lung Diseases, Interstitial; Muscular Dystrophy, Duchenne; Raynaud Disease; Transposition of Great Vessels; Erectile Dysfunction; Hypertension, Pulmonary; Prostatic Hyperplasia; Pulmonary Arterial Hypertension
Phosphodiesterase 5A inhibitor
Protein
Approved
IMMUNE SYSTEM
SUBCUTANEOUS
Acquired Immunodeficiency Syndrome; HIV Infections; Virus Diseases
Transmembrane glycoprotein gp41 inhibitor
Small molecule
Approved
Unknown
Unknown
Rhinoscleroma; Hypoglycemia; Helicobacter Infections; Peritonitis; Bacterial Infections
Unknown
Antibody
Approved
RESPIRATORY
UNKNOWN
Colonic Neoplasms; Dermatitis, Atopic; Drug Hypersensitivity; Job Syndrome; Lupus Erythematosus, Systemic; Bronchitis; Eosinophilic Esophagitis; Food Hypersensitivity; Gastroenteritis; Hypersensitivity; Immune System Diseases; Milk Hypersensitivity; Nephritis, Interstitial; Pemphigoid, Bullous; Pulmonary Disease, Chronic Obstructive; Severe Acute Respiratory Syndrome; Sinusitis; Angioedema; Cystitis, Interstitial; Peanut Hypersensitivity; Rhinitis, Allergic, Seasonal; Asthma; Lung Diseases, Obstructive; Urticaria
Ig epsilon chain C region inhibitor
Protein
Approved
OTHER
INTRAVENOUS
Obsessive-Compulsive Disorder; Autistic Disorder
Secretin receptor agonist
Small molecule
Approved
Unknown
Unknown
Constipation
Unknown
Protein
Approved
Unknown
Unknown
Down Syndrome; Alzheimer Disease; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Myocardial Infarction; Diabetes Mellitus
Insulin receptor agonist
Small molecule
Approved
IMMUNE SYSTEM; OTHER; RESPIRATORY
ORAL
Asthma; Maxillary Sinusitis; Otitis Media; Otitis Media, Suppurative; Pharyngitis; Scrub Typhus; Tonsillitis; Bacterial Infections; Infections; Pneumonia
Bacterial 70S ribosome inhibitor
Small molecule
Approved
Unknown
Unknown
Pulmonary Disease, Chronic Obstructive
Unknown
Small molecule
Approved
Unknown
Unknown
Urinary Incontinence, Urge; Prostatic Hyperplasia; Urinary Bladder, Overactive; Polyuria; Urinary Incontinence
Unknown
Small molecule
Unknown
Unknown
Unknown
Kidney Diseases; Hyperphosphatemia; Kidney Failure, Chronic; Renal Insufficiency, Chronic
Phosphate sequestering agent
Small molecule
Approved
IMMUNE SYSTEM; OTHER
ORAL
Malaria, Vivax; Urethritis; Candidiasis; Helicobacter Infections; Stomach Neoplasms; Amebiasis; Bacterial Infections; Trichomonas Infections; Vaginal Diseases; Vaginosis, Bacterial
DNA inhibitor
Small molecule
Approved
OTHER
INTRAVENOUS
Unknown
Diagnostic agent
Small molecule
Approved
Unknown
Unknown
Atrophy; Menopause
Estrogen receptor agonist
Small molecule
Approved
HEMATOLOGY; OTHER
INTRAVENOUS; SUBCUTANEOUS
Brain Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Ependymoma; Esophageal Neoplasms; Head and Neck Neoplasms; Hodgkin Disease; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liposarcoma; Lymphoma, Non-Hodgkin; Myelodysplastic-Myeloproliferative Diseases; Osteosarcoma; Ovarian Neoplasms; Tuberculosis; beta-Thalassemia; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Glioma; Hematologic Neoplasms; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Melanoma; Multiple Myeloma; Pancreatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Immunoblastic Lymphadenopathy; Leukemia; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Anemia; Anemia, Refractory, with Excess of Blasts; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms; Thrombocytopenia
DNA (cytosine-5)-methyltransferase 1 inhibitor
Small molecule
Approved
NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
ORAL
Marijuana Abuse; Anxiety Disorders; Sleep Apnea, Obstructive; Sleep Initiation and Maintenance Disorders
GABA-A receptor; anion channel positive allosteric modulator
Unknown
Approved
Unknown
Unknown
Unknown
Unknown
Small molecule
Approved
OTHER
OPHTHALMIC
Unknown
Unknown
Small molecule
Approved
Unknown
Unknown
Pharyngeal Neoplasms; Adenocarcinoma of Lung; Astrocytoma; Brain Neoplasms; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Colonic Neoplasms; Glioblastoma; Glioma; Hemorrhagic Fever, Ebola; Hepatitis C, Chronic; Kidney Neoplasms; Melanoma; Multiple Myeloma; Oligodendroglioma; Rectal Neoplasms; Adenocarcinoma, Bronchiolo-Alveolar; Adenomatous Polyposis Coli; Biliary Tract Neoplasms; Breast Neoplasms; Diffuse Intrinsic Pontine Glioma; Digestive System Diseases; Ependymoma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gliosarcoma; Hematologic Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Liver Neoplasms; Lung Neoplasms; Mesothelioma; Myelodysplastic Syndromes; Nasopharyngeal Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroendocrine Tumors; Ovarian Neoplasms; Polycythemia Vera; Prostatic Neoplasms, Castration-Resistant; Psoriasis; Skin Neoplasms; Thymoma; Urinary Bladder Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Head and Neck Neoplasms; Mouth Neoplasms; Neoplasm Metastasis; Pancreatic Neoplasms; Neoplasms
Unknown