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Total: 10647
Unknown
Approved
Unknown
Unknown
Unknown
Unknown
Enzyme
Approved
Unknown
Unknown
Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Asparagine hydrolytic enzyme
Small molecule
Approved
OTHER
ORAL
Central Nervous System Neoplasms; Diffuse Intrinsic Pontine Glioma; Esophageal Neoplasms; Glioblastoma; Glioma; Neuroblastoma; Rectal Neoplasms; Adenocarcinoma, Follicular; Astrocytoma; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Verrucous; Colorectal Neoplasms; Fallopian Tube Neoplasms; Gastrointestinal Stromal Tumors; Gliosarcoma; Head and Neck Neoplasms; Kidney Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Mesothelioma; Multiple Myeloma; Neoplasm Metastasis; Oligodendroglioma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Stomach Neoplasms; Ureteral Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Medullary; Neoplasms; Thyroid Neoplasms
Ephrin receptor inhibitor
Unknown
Approved
Unknown
Unknown
Unknown
Unknown
Small molecule
Approved
Unknown
Unknown
Hyperlipoproteinemia Type II; Cardiovascular Diseases
Unknown
Antibody
Approved
OTHER
IV (INFUSION)
Anthrax
Protective antigen binding agent
Small molecule
Approved
CARDIOVASCULAR
ORAL
Adenoma; Alzheimer Disease; Colonic Neoplasms; Non-alcoholic Fatty Liver Disease; Cardiovascular Diseases; Severe Acute Respiratory Syndrome; Hypertriglyceridemia; Pancreatitis
Unknown
Small molecule
Approved
EYE
OPHTHALMIC
Glaucoma; Glaucoma, Open-Angle; Ocular Hypertension
Prostanoid FP receptor agonist
Small molecule
Approved
MUSCULOSKELETAL; OTHER
ORAL
Celiac Disease; Kidney Diseases; Paraparesis, Tropical Spastic; Immune System Diseases; Multiple Sclerosis
Dihydroorotate dehydrogenase inhibitor
Unknown
Approved
Unknown
Unknown
Unknown
Unknown
Small molecule
Approved
NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS
ORAL
Alcoholism; Bipolar Disorder; Depressive Disorder, Major; Stress Disorders, Post-Traumatic; Torticollis; Amyotrophic Lateral Sclerosis; Diabetic Neuropathies; Essential Tremor; Migraine Disorders; Neuralgia; Peripheral Nervous System Diseases; Epilepsy, Tonic-Clonic; Lennox Gastaut Syndrome; Parkinson Disease; Epilepsy; Seizures
Glutamate receptor ionotropic AMPA antagonist
Protein
Approved
Unknown
Unknown
Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Merkel Cell; Digestive System Neoplasms; Kidney Diseases; Neuroendocrine Tumors; Prostatic Neoplasms; ACTH Syndrome, Ectopic; Adenoma; Adenoma, Islet Cell; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Medullary; Cushing Syndrome; Dumping Syndrome; Hematologic Neoplasms; Hyperglycemia; Lung Neoplasms; Meningioma; Multiple Myeloma; Neoplasms; Pain; Postoperative Complications; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Thymoma; Thyroid Neoplasms; Acromegaly; Carcinoid Tumor; Pancreatic Neoplasms; Pituitary ACTH Hypersecretion
Unknown
Small molecule
Approved
Unknown
Unknown
Carcinoma, Squamous Cell; Leukemia, Myeloid, Acute; Liver Diseases; Multiple Myeloma; Urogenital Neoplasms; Adenocarcinoma, Follicular; Adrenal Cortex Neoplasms; Astrocytoma; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Neuroendocrine; Cholangiocarcinoma; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Melanoma; Neuroendocrine Tumors; Pancreatic Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Retroviridae Infections; Salivary Gland Neoplasms; Sarcoma; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Medullary; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Thyroid Neoplasms; Neoplasms
Unknown
Small molecule
Approved
Unknown
Unknown
Alzheimer Disease; Cognitive Dysfunction
Diagnostic agent
Small molecule
Approved
OTHER; UROLOGY AND KIDNEY
ORAL
Esophageal Achalasia; Kidney Diseases; Liver Diseases; Polycystic Ovary Syndrome; Heart Failure; Hypertrophy, Left Ventricular; Pain; Prediabetic State; Urinary Bladder, Neurogenic; Cystitis, Interstitial; Kidney Calculi; Polyuria; Urinary Bladder, Overactive; Urinary Incontinence; Urinary Incontinence, Urge
Beta-3 adrenergic receptor agonist
Small molecule
Approved
GASTROINTESTINAL
ORAL
Breast Neoplasms; Irritable Bowel Syndrome; Acquired Immunodeficiency Syndrome; Diarrhea
Anoctamin-1 blocker
Small molecule
Approved
GASTROINTESTINAL; OTHER; UROLOGY AND KIDNEY
ORAL
Biliary Tract Neoplasms; Leukemia, Myeloid, Acute; Small Cell Lung Carcinoma; Bile Duct Neoplasms; Carcinoma; Carcinoma, Adenoid Cystic; Carcinoma, Renal Cell; Cholangiocarcinoma; Fallopian Tube Neoplasms; Glioblastoma; Hemangiosarcoma; Liposarcoma; Macular Degeneration; Melanoma; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Sarcoma; Stomach Neoplasms; Thyroid Neoplasms; Carcinoma, Hepatocellular; Colonic Neoplasms; Esophageal Neoplasms; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Neoplasms
Discoidin domain-containing receptor 2 inhibitor
Small molecule
Approved
Unknown
ORAL
Myasthenia Gravis; Dermatomyositis; Kidney Diseases; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic; Renal Insufficiency, Chronic; Sarcoidosis; Scleroderma, Systemic; Sjogren's Syndrome; Alopecia Areata; Colitis; Crohn Disease; Dermatitis, Atopic; Dry Eye Syndromes; Granuloma, Lethal Midline; Pneumonia; Polymyalgia Rheumatica; Pouchitis; Severe Acute Respiratory Syndrome; Wounds and Injuries; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Colitis, Ulcerative; Psoriasis; Spondylitis, Ankylosing; Immune System Diseases
Unknown
Protein
Approved
GASTROINTESTINAL; OTHER
ORAL
Adenoma; Constipation; Irritable Bowel Syndrome
Heat-stable enterotoxin receptor agonist
Small molecule
Approved
Unknown
Unknown
Myelodysplastic Syndromes; Adenocarcinoma of Lung; Blast Crisis; Carcinoma, Medullary; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Stromal Tumors; Glioblastoma; Leukemia; Leukemia, Myeloid, Acute; Small Cell Lung Carcinoma; Thyroid Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Neoplasms
Unknown
Enzyme
Unknown
Unknown
Unknown
Hematologic Neoplasms; Lymphoma; Neoplasms; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Methotrexate hydrolytic enzyme
Unknown
Approved
PEDIATRICS
INTRATRACHEAL
Cystic Fibrosis; Respiratory Distress Syndrome; Respiratory Distress Syndrome, Newborn; Respiratory Insufficiency; Meconium Aspiration Syndrome
Surfactant agent
Unknown
Approved
Unknown
Unknown
Unknown
Unknown
Small molecule
Approved
CANCER
ORAL
Carcinoma, Renal Cell; Kidney Diseases; Liver Diseases; Pancreatic Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Lymphoma, Mantle-Cell; Ovarian Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms; Breast Neoplasms; Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant
Androgen Receptor antagonist
Small molecule
Unknown
Unknown
Unknown
Ischemic Stroke; Liver Cirrhosis; Nephrotic Syndrome; Thromboembolism; Foramen Ovale, Patent; Heart Failure; Hemorrhage; Renal Insufficiency, Chronic; Takotsubo Cardiomyopathy; Acute Coronary Syndrome; Anemia, Sickle Cell; Aortic Valve Stenosis; Atrial Flutter; Hematoma; Ischemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Insufficiency; Severe Acute Respiratory Syndrome; Venous Thromboembolism; Atrial Fibrillation; Embolism; Pulmonary Embolism; Stroke; Thrombosis; Venous Thrombosis
Coagulation factor X inhibitor
Enzyme
Approved
HEMATOLOGY
INTRAVENOUS
Gaucher Disease
Glucocerebroside hydrolytic enzyme
Small molecule
Approved
Unknown
Unknown
Cardiovascular Diseases; Kidney Diseases; Liver Diseases; Marijuana Abuse; Substance-Related Disorders; Cocaine-Related Disorders; Opioid-Related Disorders; Peripheral Nervous System Diseases; Tobacco Use Disorder; Obesity
Unknown
Small molecule
Approved
Unknown
Unknown
Liver Diseases; Leprosy; Mycobacterium avium-intracellulare Infection; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tuberculosis
Unknown
Protein
Approved
Unknown
Unknown
Graft vs Host Disease; Kidney Diseases; Liver Diseases; Crohn Disease; HIV Infections; Hyperlipidemias; Malnutrition; Short Bowel Syndrome
Glucagon-like peptide 2 receptor agonist
Small molecule
Approved
RESPIRATORY
ORAL
Tuberculosis
ATP synthase inhibitor
Small molecule
Approved
RESPIRATORY
ORAL
Sinusitis; Liver Diseases; Bronchitis, Chronic; Kartagener Syndrome; Pulmonary Disease, Chronic Obstructive; Cystic Fibrosis; Respiratory Tract Diseases
Cystic fibrosis transmembrane conductance regulator positive modulator
Small molecule
Approved
OTHER
ORAL
Carcinoma, Non-Small-Cell Lung; Insulin Resistance; Malaria; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Acquired Immunodeficiency Syndrome; Pneumonia, Pneumocystis; Severe Acute Respiratory Syndrome; HIV Infections; Infections
Cytochrome P450 3A inhibitor
Unknown
Approved
Unknown
Unknown
Unknown
Unknown
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown
Antibody
Approved
PREGNANCY AND GYNECOLOGY
SINGLE-USE
Breast Neoplasms, Male; Colonic Neoplasms; Esophageal Neoplasms; Rectal Neoplasms; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Fallopian Tube Neoplasms; Hemangiosarcoma; Neoplasm Metastasis; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Inflammatory Breast Neoplasms; Ovarian Neoplasms; Stomach Neoplasms; Breast Neoplasms; Neoplasms
Receptor protein-tyrosine kinase erbB-2 inhibitor