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Total: 10647
Small molecule
Approved
Unknown
Unknown
HIV Infections
Structural capsid protein inhibitor
Small molecule
Unknown
Unknown
Unknown
Liver Diseases; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency; Sleep Apnea, Obstructive; Sleep Initiation and Maintenance Disorders
Orexin receptor antagonist
Small molecule
Approved
Unknown
Unknown
Epilepsies, Partial; Epilepsy; Epilepsy, Complex Partial; Fragile X Syndrome; Smoking Cessation; Spasms, Infantile; Stress Disorders, Post-Traumatic; Tuberous Sclerosis; Seizures; Status Epilepticus
GABA-A receptor; anion channel positive allosteric modulator
Protein
Approved
Unknown
Unknown
Breast Neoplasms; Lymphoma; Neutropenia
Unknown
Oligonucleotide
Approved
Unknown
Unknown
Amyloid Neuropathies, Familial
Unknown
Small molecule
Approved
Unknown
Unknown
Heart Failure; Cardiomyopathy, Hypertrophic
Unknown
Combination
Approved
Unknown
Unknown
Unknown
Unknown
Antibody
Approved
Unknown
Unknown
Kidney Neoplasms; Esophageal Neoplasms; Hematologic Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Multiple Myeloma; Myelodysplastic Syndromes; Peritoneal Neoplasms; Adenocarcinoma, Follicular; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Pancreatic Ductal; Cholangiocarcinoma; Colorectal Neoplasms; Dysgerminoma; Fallopian Tube Neoplasms; Genital Neoplasms, Female; Glioblastoma; Head and Neck Neoplasms; HIV Infections; Lung Neoplasms; Mesothelioma; Neoplasms, Germ Cell and Embryonal; Neuroendocrine Tumors; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Seminoma; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Thyroid Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Melanoma; Neoplasms; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Urogenital Neoplasms
Cytotoxic T-lymphocyte protein 4 inhibitor
Small molecule
Approved
Unknown
Unknown
Dermatitis, Atopic; Psoriasis
Aryl hydrocarbon receptor agonist
Small molecule
Small molecule
Unknown
Unknown
Leukemia, Myeloid, Acute; Myelodysplastic Syndromes
Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor
Protein
Approved
Unknown
Unknown
Hemorrhage; Liver Failure; Shock, Septic; Hemoptysis; Liver Cirrhosis; Renal Insufficiency
Unknown
Protein
Approved
Unknown
Unknown
Non-alcoholic Fatty Liver Disease; Diabetes Mellitus, Type 2; Obesity
Gastric inhibitory polypeptide receptor agonist
Small molecule
Approved
Unknown
Unknown
Immune System Diseases; Kidney Diseases; Liver Diseases; Colitis, Ulcerative; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic; Lupus Nephritis; Arthritis, Psoriatic; Psoriasis
Tyrosine-protein kinase TYK2 negative allosteric modulator
Small molecule
Approved
Unknown
Unknown
Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Graft vs Host Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Colorectal Neoplasms; Hodgkin Disease; Leukemia; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Myeloproliferative Disorders; Primary Myelofibrosis; Prostatic Neoplasms, Castration-Resistant; Severe Acute Respiratory Syndrome
Tyrosine-protein kinase JAK2 inhibitor
Unknown
Approved
Unknown
Unknown
Unknown
Unknown
Small molecule
Approved
Unknown
Unknown
Kidney Diseases; Liver Diseases; Psoriasis; Dermatitis, Atopic
Tyrosine-protein kinase JAK1 inhibitor
Small molecule
Investigational
Unknown
Unknown
Carcinoma, Non-Small-Cell Lung; Breast Neoplasms; Carcinoma, Hepatocellular; Neoplasms; Cholangiocarcinoma; Sarcoma
Fibroblast growth factor receptor inhibitor
Small molecule
Approved
Unknown
Unknown
Anemia, Sickle Cell; Thalassemia; Anemia
Unknown
Enzyme
Approved
Unknown
Unknown
Niemann-Pick Diseases
Sphingomyelin hydrolytic enzyme
Oligonucleotide
Approved
Unknown
Unknown
Amyotrophic Lateral Sclerosis
SOD1 mRNA inhibitor
Small molecule
Approved
Unknown
Unknown
Essential Hypertension; Diabetes Mellitus; Diabetes Mellitus, Type 2
Sodium/glucose cotransporter 2 inhibitor
Antibody
Approved
Unknown
Unknown
Arthritis, Rheumatoid; Arthritis, Psoriatic; Hidradenitis Suppurativa; Psoriasis; Spondylitis, Ankylosing
Interleukin 17A inhibitor
Protein
Approved
Unknown
Unknown
Wounds and Injuries; Brain Concussion; Brain Injuries; Fragile X Syndrome; Rett Syndrome
Unknown
Small molecule
Approved
Unknown
Unknown
Multiple Myeloma; Neoplasms; Breast Neoplasms; Pancreatic Neoplasms; Fibromatosis, Aggressive
Unknown
Small molecule
Approved
Unknown
Unknown
Kidney Diseases; Liver Diseases; Hot Flashes
Neurokinin 3 receptor antagonist
Small molecule
Approved
Unknown
Unknown
Mycoses
Unknown
Small molecule
Approved
Unknown
Unknown
Depressive Disorder; Essential Tremor; Parkinson Disease; Depression, Postpartum; Depressive Disorder, Major
Unknown
Small molecule
Approved
Unknown
Unknown
Cocaine-Related Disorders; Depressive Disorder
Unknown
Small molecule
Approved
Unknown
Unknown
Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Mantle-Cell
Tyrosine-protein kinase BTK inhibitor
Small molecule
Approved
Unknown
Unknown
Unknown
PI3-kinase p110-delta subunit inhibitor
Small molecule
Approved
Unknown
Unknown
Liver Diseases; Melanoma; Breast Neoplasms; Friedreich Ataxia
Unknown
Small molecule
Approved
Unknown
Unknown
Blepharitis
Unknown
Small molecule
Approved
Unknown
Unknown
Wounds and Injuries; Peripheral Vascular Diseases; Anemia
Hypoxia-inducible factor prolyl hydroxylase inhibitor
Protein
Approved
Unknown
Unknown
Amyotrophic Lateral Sclerosis; Hemoglobinuria, Paroxysmal; Myasthenia Gravis; Severe Acute Respiratory Syndrome
Complement C5 inhibitor
Small molecule
Approved
Unknown
Unknown
Glomerulonephritis; Glomerulonephritis, Membranous; Atypical Hemolytic Uremic Syndrome; Glomerulonephritis, IGA; Hemoglobinuria, Paroxysmal
Complement factor B inhibitor